Results 221 to 230 of about 23,372,398 (298)

Automated Diagnosis of Infantile Skull Fractures From X-Ray Images Using an Ensemble Deep Learning Model. [PDF]

J Korean Med Sci
Lee HS, Kang J, Kim SE, Kwon LM, Kim JH, Cho BJ.   +5 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Review of the Chinese species of the genus <i>Reptalus</i> Emeljanov, 1971 (Hemiptera, Fulgoromorpha, Cixiidae), with description of a new species. [PDF]

Zookeys
Lv SS, Li ZZ, Zhi Y, Zhang YB, Chen XS, Yang L.   +5 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Integrative Taxonomy Supports Four New Species in the <i>Amphinemura sinensis</i> Species Group (Plecoptera: Nemouridae) from China. [PDF]

Insects
Wang Y, Wang G, Yang D, Li W.
europepmc   +1 more source

Reassessment of the Early Cretaceous North American "troodontid" Geminiraptor suarezarum as a therizinosaurian and mosaic evolution of coelurosaurian maxillae. [PDF]

PLoS One
Freimuth WJ, Lively JR, Zanno LE.
europepmc   +1 more source

Physicians' Judgments About Off-Label Medical Narcotic Use and Dose Reduction Responses: A South Korean Cross-Sectional Survey. [PDF]

Medicina (Kaunas)
Lee Y, Minn YK, Kim JE.
europepmc   +1 more source

Pilot Study: Abdominoplasty Combining Median Rectus Plication and External Oblique Muscle Advancement: The Internal Corset Technique. [PDF]

Plast Reconstr Surg Glob Open
Goncalves RFP.
europepmc   +1 more source