Results 61 to 70 of about 8,017,094 (307)
Evolutionary interplay between viruses and R‐loops
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi+4 more
wiley +1 more source
A UML PROFILES FOR VIEWPOINT-ORIENTED MODELING
The viewpoint-oriented modeling consists in providing an unique modelaccessible by users with various access rights according to their needs. The system isrepresented as sub-systems (called sub-models). This cutting makes the design of systemeasier by an
Abdellatif Hair
doaj
Circulating histones as clinical biomarkers in critically ill conditions
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez+17 more
wiley +1 more source
The River Danube as an Attraction in Positioning Hotels along its Riverside Capitals [PDF]
The hotel is part of the tourism suprastructure; it provides the conditions of the complex supply set of the people’s temporary home.
Ákos Kátay, Róbert Kiss
doaj
Dealing with the unexpected: consumer responses to direct-access BRCA mutation testing [PDF]
Background. Inherited BRCA gene mutations convey a high risk for breast and ovarian cancer, but current guidelines limit BRCA mutation testing to women with early-onset cancer and relatives of mutation-positive cases. Benefits and risks of providing this
Uta Francke+6 more
doaj +2 more sources
Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases
Accurate protein synthesis is crucial for life. The key players are aminoacyl‐tRNA synthetases (AARSs), which read the genetic code by pairing cognate amino acids and tRNAs. AARSs establish high amino acid selectivity by employing physicochemical limits in molecular recognition.
Igor Zivkovic+2 more
wiley +1 more source
Single‐cell insights into the role of T cells in B‐cell malignancies
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Extracellular vesicles (EVs) mediate intercellular communication in tumor immune microenvironments. However, their role in B‐cell malignancies remains poorly defined, owing to biological complexity and technical challenges in EV isolation and analysis.
Daniel Bachurski, Michael Hallek
wiley +1 more source
Marie’s cycle is the story of an endless separation. The homodiegetic narrator gazes at Marie, the woman he loves, when she is next to him. However, she often hides from him. And what cannot be seen cannot be known either.
Frédéric Clamens-Nanni
doaj
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu+17 more
wiley +1 more source