ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Seedling image analysis and traditional tests to evaluate onion seed vigor
Journal of Seed Science: The aim of this study was to verify the possibility of using computerized seedling image analysis to detect differences in vigor among onion seed lots and to compare this analysis with traditional vigor tests.
Nayara Roberto Gonçalves +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Antioxidant response of bean seeds with contrasting vigor to cold stress
Pesquisa Agropecuária TropicalSeed germination is a critical part of plant emergence and establishment in the field, and cold stress can affect the emergence potential and seedling formation.
Matheus Santin Padilha +2 more
doaj +1 more source
Are architectural traits at florewing stage relevant to account for yield advantage in hybrid rice? [PDF]
, 2006 Yield advantage of hybrid rice over conventional inbred rice in tropical favorable environments, up to 15%, is commonly and simply attributed to higher biomass production due to higher seedling vigor and higher harvest index.
Bueno, Crisanta Sunio +2 more
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Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
PENGARUH RIZOBAKTERI PEMACU PERTUMBUHAN TANAMAN DAN PUPUK KANDANG TERHADAP VIABILITAS DAN VIGOR KEKUATAN TUMBUH BENIH KAKAO (THEOBROMA CACAO L.) [PDF]
, 2016 HENGKI HERMAWAN. Pengaruh Rizobakteri Pemacu Pertumbuhan Tanaman (RPTT) dan Pupuk Kandang Terhadap Viabilitas dan Vigor Kekuatan Tumbuh Benih Kakao (Theobroma cacao L.).
Hengki Hermawan
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Seed germination responses of sorghum lines and cultivars under salinity stress conditions [PDF]
علوم و فناوری بذر ایران, 2017 To evaluate the effect of salinity stress on germination indices of sorghum, this experiment was conducted using a factorial arrangement based on a completely randomized design (CRD) with three replications at Cereal laboratory of College of Agriculture,
E. Shakeri +3 more
doaj
VIABILITAS DAN VIGOR BENIH PADI (ORYZA SATIVA .L) VARIETAS INTRODUKSI DAN GALUR POTENSIAL PADA POSISI MALAI YANG BERBEDA UNTUK MUSIM TANAM RENDENGAN [PDF]
, 2018 RINGKASANPenelitian ini dilaksanakan di dua lokasi yaitu Desa Samahani Kecamatan Kuta Malaka, Kabupaten Aceh Besar dan Laboratorium Teknologi Benih, Fakultas Pertanian Universitas Syiah Kuala, Darussalam Banda Aceh.
Reva Riski
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