Results 141 to 150 of about 52,710 (265)

Calbindin stratifies midbrain dopaminergic neurons governing distinct aspects of locomotion. [PDF]

Proc Natl Acad Sci U S A
Bolduc C, Oram C, Donovan S, Bach H, Liu M, Marier R, Sharpe M, Liu S, Campeau C, Spencer CD, Martin SA, Awatramani R, Poulin JF.   +12 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

The Spatiotemporal Genetic Architecture of Seed Vigor in Upland Cotton. [PDF]

Adv Sci (Weinh)
Wang L, Dai J, Zhao T, Zhao S, Wu H, Pan J, Hao Y, Nie K, Yu L, Zhu Y, Zhao X, Huang K, Zhang M, Zhao Y, Jiang Y, Wang S, Pan Y, Chen Y, Lin Y, Shi W, Deng Y, Han J, Li J, Long X, Wang J, Zhang Z, Han Z, Si Z, Ju L, Li J, Zhang T, Zhou J, Guan X.   +32 more
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Academic Engagement and Contextual Factors Associated with Academic Performance in First-Year Medical Students: A Cross-Sectional Study. [PDF]

Adv Med Educ Pract
Flores V, Ríos H, González Gentili C, Donato M, Rapacioli M.   +4 more
europepmc   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Genome-wide association study identifies key loci and candidate genes for seed vigor in upland cotton (<i>Gossypium hirsutum</i> L.). [PDF]

Front Plant Sci
Liu H, Wang Z, Sun H, Zou Y, Ma J, Wu S, Abdukerim S, Zheng K, Chen Q, Deng X.   +9 more
europepmc   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Personal goal facilitation, burnout and work engagement: the role of self-discrepancy. [PDF]

Front Psychol
Tan JJX, Tang BW.
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source