Results 21 to 30 of about 190,404 (265)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Exploring the responses of non-churchgoers to a cathedral pre-Christmas son et lumiere

HTS Teologiese Studies/Theological Studies
Two conceptual strands of research within the field of cathedral studies have theorised the capacity of Anglican cathedrals to engage more successfully than parish churches with the wider non-churchgoing community.
Ursula McKenna, Leslie J. Francis, Andrew Village, Francis Stewart   +3 more
doaj   +1 more source

Technoscapes and mediascapes influence on village and city relations in Manggarai, East Nusa Tenggara

Simulacra, 2020
The development of infrastructure and information technology has a significant impact on the relationship between Ruteng, the capital of the Manggarai district, and the surrounding villages.
Ans Prawati Yuliantari
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Blastulation and ploidy prediction using morphology assessment in 33,999 day-3 embryos

Scientific Reports
Although contemporary practice in in vitro fertilization (IVF) favors embryo transfer at blastocyst stage, several centres worldwide employ cleavage-stage Day-3 embryo transfers.
Ibrahim Elkhatib, Erkan Kalafat, Aşina Bayram, Andrea Abdala, Alberto Linan, Laura Melado, Baris Ata, Barbara Lawrenz, Human M. Fatemi, Daniela Nogueira   +9 more
doaj   +1 more source

The State's Responsibility in Preserving Local Culture: A Constitutional Law Perspective on the Practice of Akapalumba Jarangk

Volksgeist
The state holds a fundamental responsibility to protect the human rights of its citizens, including the right to safety, as outlined in national constitutions and international law.
Reza Amarta Prayoga, Sahajuddin Sahajuddin, Ansaar Ansaar, Abdul Hafid, Sritimuryati Sritimuryati, Entis Sutisna   +5 more
doaj   +1 more source

Development of flexibility by means of stretching in karate players at the stage of initial training [PDF]

Физическое воспитание и студенческий спорт
In martial arts, good flexibility provides an athlete with freedom and speed, economy of movement, increases efficiency of applying effort when performing a variety of physical exercises, even the most difficult ones.
Pavlovskaya, Olga A., Shakirova, Olga V., Perepelitsa, Elena E., Palchenko, Alexander P.   +3 more
doaj   +1 more source

DAMPAK SOSIAL PARIWISATA TERHADAP MASYARAKAT DESA EKOWISATA PAMPANG GUNUNG KIDUL MENUJU DESA EKOWISATA BERKELANJUTAN

Jurnal Sosiologi Reflektif, 2020
Changes in tourism that are currently developing from mass tourism to form a special interest tourism encourage one of the villages in Paliyan District, Pampang to become an Ecotourism village by carrying out the concepts of conservation and education ...
Elisa Dwi Rohani, Yitno Purwoko
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Evaluation of residential reorganization from the living environment before and after group relocation (part 1): Focusing on the living environment and community

Japan Architectural Review, 2023
The reorganization of residential areas through mass relocation has had 3 impacts on the living environment of the village. Owing to the reduction in the area of the site, the residential space has lost the room for inviting non‐family members.
Takayuki Tomobuchi, Osamu Tsukihashi, Juichi Yamazaki   +2 more
doaj   +1 more source