Results 21 to 30 of about 728,693 (265)

RUBY® – a tetravalent (2+2) bispecific antibody format with excellent functionality and IgG-like stability, pharmacology and developability properties

mAbs
Despite the large number of existing bispecific antibody (bsAb) formats, the generation of novel bsAbs is still associated with development and bioprocessing challenges.
Barnabas Nyesiga, Mattias Levin, Anna Säll, Anna Rosén, Kim Jansson, Sara Fritzell, Karin Hägerbrand, Dietmar Weilguny, Laura von Schantz   +8 more
doaj   +1 more source

Wood Village Notice of Adopted Amendment (2012-05-15) [PDF]

, 2012
205 pp. Adopted 2012-05-15. Department of Land Conservation and Development Notice of Adopted AmendmentI ipdate the Cuy of Wood Village Transportation System Plan focusing on pedestrian, bicycle and public transportation ...
Wood Village
core  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Exploring the responses of non-churchgoers to a cathedral pre-Christmas son et lumiere

HTS Teologiese Studies/Theological Studies
Two conceptual strands of research within the field of cathedral studies have theorised the capacity of Anglican cathedrals to engage more successfully than parish churches with the wider non-churchgoing community.
Ursula McKenna, Leslie J. Francis, Andrew Village, Francis Stewart   +3 more
doaj   +1 more source

Development of flexibility by means of stretching in karate players at the stage of initial training [PDF]

Физическое воспитание и студенческий спорт
In martial arts, good flexibility provides an athlete with freedom and speed, economy of movement, increases efficiency of applying effort when performing a variety of physical exercises, even the most difficult ones.
Pavlovskaya, Olga A., Shakirova, Olga V., Perepelitsa, Elena E., Palchenko, Alexander P.   +3 more
doaj   +1 more source

Technoscapes and mediascapes influence on village and city relations in Manggarai, East Nusa Tenggara

Simulacra, 2020
The development of infrastructure and information technology has a significant impact on the relationship between Ruteng, the capital of the Manggarai district, and the surrounding villages.
Ans Prawati Yuliantari
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The State's Responsibility in Preserving Local Culture: A Constitutional Law Perspective on the Practice of Akapalumba Jarangk

Volksgeist
The state holds a fundamental responsibility to protect the human rights of its citizens, including the right to safety, as outlined in national constitutions and international law.
Reza Amarta Prayoga, Sahajuddin Sahajuddin, Ansaar Ansaar, Abdul Hafid, Sritimuryati Sritimuryati, Entis Sutisna   +5 more
doaj   +1 more source

DAMPAK SOSIAL PARIWISATA TERHADAP MASYARAKAT DESA EKOWISATA PAMPANG GUNUNG KIDUL MENUJU DESA EKOWISATA BERKELANJUTAN

Jurnal Sosiologi Reflektif, 2020
Changes in tourism that are currently developing from mass tourism to form a special interest tourism encourage one of the villages in Paliyan District, Pampang to become an Ecotourism village by carrying out the concepts of conservation and education ...
Elisa Dwi Rohani, Yitno Purwoko
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source