Results 51 to 60 of about 1,173,578 (313)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The influence of village funds on community empowerment in tourism villages

Jurnal Inovasi Ilmu Sosial dan Politik (JISoP), 2023
This study aims to measure how much influence village funds have on community empowerment in Pujon Kidul Tourism Village using quantitative methods. This study collected primary data from closed questionnaires which were distributed randomly to 100 respondents including village government, youth leaders and community leaders.
Noora Fithriana, Fransiska Eka, Cahyo Sasmito   +2 more
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The Influence of Village Leadership and Village Funds on Poverty

Journal of Posthumanism
Poverty is a problem in the village, therefore a strategy is needed, namely the Village Fund policy. However, the success of its utilization depends on the quality of leadership. Therefore, transparent and visionary village leaders are needed so that the funds are effective.
Alinursal Noer, Syamsul Amar, Hasdi Aimon   +2 more
openaire   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

ANALYSIS OF VILLAGE FUND MANAGEMENT ON DEVELOPMENT AT PALALAKKANG VILLAGE

SIMAK, 2022
This study aims to determine how the management of the village fund management on the development of Desa Palalakkang. The type of research used is the qualitative research metode.The processed data is the result of interviews with palalakkang village staff. Data colettion methods used in this study is observation, interview, and documentation.
Murniady Muchran, Nuryahya Nuryahya, Firman Syah, Muchriady Muchran   +3 more
openaire   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Wood Village Notice of Adopted Amendment (2012-05-15) [PDF]

, 2012
205 pp. Adopted 2012-05-15. Department of Land Conservation and Development Notice of Adopted AmendmentI ipdate the Cuy of Wood Village Transportation System Plan focusing on pedestrian, bicycle and public transportation ...
Wood Village
core  

Accountability of village fund management during the covid-19 pandemic (Study on village government in Dayun District, Siak Regency)

The Indonesian Accounting Review, 2023
This study aims to examine the effect of the competence of village government officials, citizen participation, application of information technology, organizational commitment, transparency, and internal control systems on the accountability of village ...
Sahala Purba, Junika Napitupulu, Andro Siregar   +2 more
doaj   +1 more source