Results 141 to 150 of about 558,823 (337)

Bioprinting‐Assisted Tissue Assembly to Investigate Endothelial Cell Contributions in Cardiac Fibrosis and Focal Fibrosis Modeling

open access: yesAdvanced NanoBiomed Research, EarlyView.
GA: Bioprinting‐assisted tissue assembly, a method for generating versatile and complex tissue constructs, is employed to investigate the contribution of endothelial cells (ECs) in cardiac fibrosis. ECs modulate fibrotic responses not only by preventing significant tissue stiffening and contractile impairment but also by exhibiting endothelial‐to ...
Dong Gyu Hwang   +6 more
wiley   +1 more source

The Chemistry and Biology of the Tetrodotoxin Natural Product Family

open access: yesAngewandte Chemie International Edition, EarlyView.
Tetrodotoxin is best known as the poison of the pufferfish, which is a delicacy in Japanese cuisine. Its toxicity arises from the selective blockage of NaV channels, which is depicted for the NaV1.7 pore, highlighting the DEKA motif, which permeates sodium ions.
Benedikt Nißl   +6 more
wiley   +1 more source

Biosynthesis of the Red Algal Diterpene Peyssonnosol in Bacteria

open access: yesAngewandte Chemie International Edition, EarlyView.
Two terpene synthases derived from Anaerolineae bacteria catalyse the biosynthesis of peyssonnosene‐type diterpenes from red algae. Site‐directed mutagenesis enabled a partial functional switch, resulting in the formation of additional byproducts. The intricate cyclisation mechanisms were investigated through isotopic labelling experiments and density ...
Zhiyong Yin   +10 more
wiley   +1 more source

Porous Organic Cages as Building Blocks for Framework Materials

open access: yesAngewandte Chemie International Edition, EarlyView.
Confined nanospaces are key to the design of porous materials like COFs, MOFs, and molecular cages for applications in molecular recognition, catalysis, and energy storage. This Minireview explores the rising role of porous organic cages (POCs) as versatile synthons, highlighting their integration into Cage‐COFs, Cage‐MOFs, and Cage‐POPs.
Marcos Martínez‐Fernández   +2 more
wiley   +1 more source

EVA implants for controlled drug delivery to the inner ear

open access: yesInternational Journal of Pharmaceutics: X
This study evaluated the potential of poly(ethylene vinyl acetate) (EVA) copolymers as matrix formers in miniaturised implants, allowing to achieve controlled drug delivery into the inner ear.
Y. Bedulho das Lages   +9 more
doaj  

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