Covalent Reprogramming of Kinase Binders to Modulate Protein Abundance
Electrophilic remodeling of a broad‐spectrum kinase binder reveals how subtle chemical changes reprogram protein fate. An acrylamide analog of a multi‐kinase binder selectively stabilizes Aurora kinase A (AURKA) by suppressing its ubiquitination, while a short‐linker variant converts this stabilizer into a degrader.
Chen Mozes +4 more
wiley +1 more source
Crystalline Half-Parent Vinyl-tetrylenes: Synthesis and Coordination Chemistry. [PDF]
Schulz A, Hadlington TJ.
europepmc +1 more source
Toward Predictive Theory in Single‐Atom Catalysis
A lifecycle‐oriented framework reframes modeling in single‐atom catalysis. By combining ensemble‐based descriptions with explicit validation against experimental observables, the approach defines the scope of theory across catalyst synthesis, activity, stability, and safety, clarifying where quantitative insight is possible and where interpretation ...
Andrea Ruiz‐Ferrando +3 more
wiley +1 more source
Kinetics of the reactions of the p-methoxy-substituted benzhydryl cation with various alkenes and 1,3-dienes [PDF]
Irrgang, Bernhard +3 more
core +1 more source
Catechol-derived propargyl diol cyclizations with malonyl dichloride: substituent effects on the formation of macrocyclic esters and their hydrochlorinated adducts. [PDF]
Lefkaritis G +3 more
europepmc +1 more source
This review systematically explores the recent advances in in situ polymerized composite polymer electrolytes (CPEs) for solid‐state lithium batteries. It covers the fundamentals of reaction mechanisms, monomer chemistry, and their impact on interfacial stability, ionic conductivity, and electrochemical performance.
Jialin Li +9 more
wiley +1 more source
Electrochemical Three-Component Synthesis of Vinyl Sulfonamides via Decarboxylative Sulfonylation of Cinnamic Acids. [PDF]
Chien PC, Kelm H, Manolikakes G.
europepmc +1 more source
Shadow‐Calibrated Stereo Vision for Colorimetric Sweat Analysis
By establishing a mathematical model that reconstructs 3D structures through geometric features of object shadows under controlled illumination, and combining it with Convolutional Neural Network‐based 2D image analysis for volumetric calibration, this work enables highly accurate 3D morphological reconstruction.
Ting Xiao +7 more
wiley +1 more source
Stereospecific alkenylation of carboranes: copper-catalyzed access to pyridylcarboranyl alkenes. [PDF]
Li P +7 more
europepmc +1 more source
A mechanically interlocked polyrotaxane hydrogel integrates sliding macrocycles within a covalent network, yielding skin‑like softness, high stretchability, robust adhesion, and stable ionic conductivity. This multifunctional interface enables simultaneous high‑fidelity monitoring of human motion and epidermal electrophysiological signals (ECG/EMG ...
Hao‐Zheng Huang +9 more
wiley +1 more source

