Results 121 to 130 of about 2,254,091 (312)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Hidden Violence: Preventing and Responding to Sexual Exploitation and Sexual Abuse of Adolescent Boys [PDF]
, 2012 Boys and girls experience sexual violence and sexual exploitation in gender differentiated ways. Numerous national-level surveys have found that boys experience these forms of violence at lower rates than girls do, but at rates that nevertheless merit ...
Gary Barker, Piotr Pawlak
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
BMJ OpenObjectives Despite the important role of healthcare services in trauma recovery, many survivors of violence do not seek help. This study aims to examine rates of healthcare utilisation, including differences for physical violence versus rape, gender and ...
Maria Teresa Grønning Dale +6 more
doaj +1 more source
Theorising homophobic hate crime in Northern Ireland [PDF]
, 2008 Homophobic violence in Northern Ireland is an area which has come underthe spotlight in the wake of the ongoing, successful, peace process. Tosome degree the peace process itself has been accused of facilitating andoverlooking homophobic violence.
Duggan, Marian
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Preventive Medicine ReportsObjective: This study investigates the association between replacement thinking, status threat perceptions, and the endorsement of political violence among non-Hispanic white adults in the United States. It explores how perceived threats to social status
Paul M. Reeping +5 more
doaj +1 more source
The Consequences of Structural Racism, Concentrated Poverty, and Violence on Young Men and Boys of Color [PDF]
, 2011 Defining violence broadly as "systemic injury directed against a group or geographic area," this research brief describes the scope of violence that black young men and boys face as a result of structural conditions.
Carol Silverman +2 more
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source