Results 281 to 290 of about 2,052,059 (368)

Advances in Microfluidic Cochlea‐On‐A‐Chip

open access: yesAdvanced Science, EarlyView.
This review systematically examines diverse cell sources for inner ear organoids and outlines stepwise induction protocols. Furthermore, it discusses current applications and prospective developments of cochlea‐on‐a‐chip technologies in areas such as deafness modeling, mechanistic studies, and drug evaluation, with particular focus on gene‐therapy drug
Tian Shen   +10 more
wiley   +1 more source

Structural Insights into an Antiparallel Chair‐Type G‐Quadruplex From the Intron of NOP56 Oncogene

open access: yesAdvanced Science, EarlyView.
This study first reports that the intron 1 of NOP56 oncogene forms an antiparallel chair‐type G4 structure composed of two G‐tetrads and one C∙G∙C∙G tetrad. NOP56 gene transcription can be inhibited by PDS that binds and stabilizes NOP56‐G4. Solution NMR structures of the free NOP56‐G4 and NOP56‐G4‐PDS complex provide valuable insights into G4 ...
Zhenzhen Yan   +11 more
wiley   +1 more source

Violence Against Doctors

open access: hybrid, 1970
Mohammad Ashik Imran Khan   +5 more
openalex   +2 more sources

Viral‐Mediated Connexin 26 Expression Combined with Dexamethasone Rescues Hearing in a Conditional Gjb2 Null Mice Model

open access: yesAdvanced Science, EarlyView.
AAV2.7m8 serotype combined with the gfaABC1D promoter targets infection of supporting cells (SCs). AAV2.7m8‐gfaABC1D‐Gjb2 administration to mice results in excessive immune responses. The combination of AAV2.7m8‐gfaABC1D‐Gjb2 with dexamethasone (DEX) shows a synergistic effect and enhances the gene therapy effect in a conditional Cx26 null mice model ...
Xiaohui Wang   +8 more
wiley   +1 more source

The Elimination of Violence Against Women

open access: hybrid, 1970
Lebanese American University
openalex   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

open access: yesAdvanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao   +14 more
wiley   +1 more source

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