Results 301 to 310 of about 2,363,588 (364)

Multifunctional Neural Probes Enable Bidirectional Electrical, Optical, and Chemical Recording and Stimulation In Vivo

open access: yesAdvanced Materials, EarlyView.
Convergence drawing is used to create flexible, microscale, multifunctional fiber‐based neural probes. Optimized materials selection enables individual devices to perform neural recording, electrical stimulation, optogenetics, fiber photometry, fluid delivery, and voltammetric neurotransmitter detection in rodents.
Nicolette Driscoll   +16 more
wiley   +1 more source

Selective Lipolysis by Photoactivation of Chaperone‐Mediated Autophagy Using Adipocyte Membrane‐Coated Nanoparticle in Hydrogel

open access: yesAdvanced Materials, EarlyView.
Adipocyte membrane‐coated nanoparticles loaded with rosiglitazone in hydrogel offer an alternative approach to conventional obesity treatments. This system selectively targets adipocytes, inducing lipolysis by activating chaperone‐mediated autophagy through mild photothermal stimulation.
Jaehyun Choi   +8 more
wiley   +1 more source

Bi‐Functional Topospecific Nanoparticles to Promote Immune‐Tumor Cell Engagement as A New Immunotherapeutic Strategy

open access: yesAdvanced Materials, EarlyView.
A Janus‐engineered nanoplatform (J‐pHLIP‐PD1), featuring separate tumor‐ and immune‐targeting faces, bridges melanoma cells and cytotoxic T lymphocytes using toposelective pHLIP and anti‐PD‐1 presentation. This strategy elicits robust antitumor responses, promotes immunogenic tumor cell death, suppresses lung metastasis in vivo, and provides a modular,
Alba Ortuño‐Bernal   +9 more
wiley   +1 more source

The Complex Dynamics of Violence and Burnout in Healthcare: A Closer Look at Physicians and Nurses. [PDF]

open access: yesInt Nurs Rev
Çakır O   +4 more
europepmc   +1 more source

Implantable Light‐Powered Human Designer Cells for Electrical Energy Generation

open access: yesAdvanced Materials, EarlyView.
Inspired by the eel's electric organ, a miniature implantable biohybrid device is developed to generate electricity under light activation. The device utilizes a light‐dependent ion gradient formation that induced by genetically engineered human designer cells that express light‐sensitive membrane ion channels and proton pumps, working in synergy with ...
Shuai Xue   +5 more
wiley   +1 more source

MUTE‐Seq: An Ultrasensitive Method for Detecting Low‐Frequency Mutations in cfDNA With Engineered Advanced‐Fidelity FnCas9

open access: yesAdvanced Materials, EarlyView.
An advanced‐fidelity CRISPR nuclease, FnCas9‐AF2, is rationally engineered to discriminate single‐base mismatches with unprecedented level precision. Integrated into the MUTE‐Seq workflow, FnCas9‐AF2 depletes wild‐type cell‐free DNA, thereby exposing rare tumor‐derived mutant DNA (a molecular “needle in a haystack”).
Sunghyeok Ye   +20 more
wiley   +1 more source

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