Results 261 to 270 of about 140,855 (312)

A Comprehensive CYP2D6 Drug–Drug–Gene Interaction Network for Application in Precision Dosing and Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Conducting clinical studies on drug–drug‐gene interactions (DDGIs) and extrapolating the findings into clinical dose recommendations is challenging due to the high complexity of these interactions. Here, physiologically‐based pharmacokinetic (PBPK) modeling networks present a new avenue for exploring such complex scenarios, potentially informing ...
Simeon Rüdesheim, Helena Leonie Hanae Loer, Denise Feick, Fatima Zahra Marok, Laura Maria Fuhr, Dominik Selzer, Donato Teutonico, Annika R. P. Schneider, Juri Solodenko, Sebastian Frechen, Maaike van der Lee, Dirk Jan A. R. Moes, Jesse J. Swen, Matthias Schwab, Thorsten Lehr   +14 more
wiley   +1 more source

Violence against women and girls: more RESPECT needed. [PDF]

Lancet Reg Health Am
The Lancet Regional Health-Americas.
europepmc   +1 more source

Comprehensive DSRCT multi‐omics analyses unveil CACNA2D2 as a diagnostic hallmark and super‐enhancer‐driven EWSR1::WT1 signature gene

Cancer Communications, EarlyView.
Florian Henning Geyer, Alina Ritter, Seneca Kinn‐Gurzo, Tobias Faehling, Jing Li, Armin Jarosch, Carine Ngo, Endrit Vinca, Karim Aljakouch, Azhar Orynbek, Shunya Ohmura, Thomas Kirchner, Roland Imle, Laura Romero‐Pérez, Juan Díaz‐Martín, Stefanie Bertram, Enrique de Álava, Clémence Henon, Sophie Postel‐Vilnay, Ana Banito, Martin Sill, Yvonne Versleijen‐Jonkers, Benjamin Friedrich Berthold Mayer, Martin Ebinger, Monika Sparber‐Sauer, Sabine Stegmaier, Daniel Baumhoer, Wolfgang Hartmann, Jeroen Krijgsveld, David Horst, Olivier Delattre, Patrick Joseph Grohar, Thomas Georg Phillip Grünewald, Florencia Cidre‐Aranaz   +33 more
wiley   +1 more source

Identification and Clinical Evaluation of Potential Biomarkers for Breast Cancer Resistance Protein (BCRP/ABCG2)

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical inhibition and genetic variation of the Breast Cancer Resistance Protein (BCRP/ABCG2) efflux transporter can significantly influence drug exposure, highlighting the need for reliable BCRP functional biomarkers. This study aimed to identify and evaluate biomarkers predictive of BCRP function in humans.
Andrew M. Riselli, Sook Wah Yee, Jia Yang, Claire M. Brett, Kelsey Trumbach, Xujia Zhou, Renmeng Liu, Xiaomin Liang, Yurong Lai, Runlan Huo, Yongjun Xue, Hong Shen, Lei Zhang, Xinning Yang, Qi Liu, Shiew‐Mei Huang, Kathleen M. Giacomini   +16 more
wiley   +1 more source

Violence against women and its effects on mental health and quality of life: A study of Myanmar migrant workers in Central Thailand. [PDF]

J Migr Health
Linn N, Chuemchit M, Mon AS, Boonshuyar C.   +3 more
europepmc   +1 more source

Improved Prediction of CYP2D6 Catalyzed Drug Metabolism by Taking Variant Substrate Specificities and Novel Polymorphic Haplotypes into Account

Clinical Pharmacology &Therapeutics, EarlyView.
The polymorphic CYP2D6 enzyme plays a pivotal role in the metabolism of approximately 25% of clinically prescribed drugs. However, the impact of specific genetic variants on the interindividual variability in CYP2D6‐mediated drug metabolism remains insufficiently quantified. This translational study sought to address this gap by analyzing the genotypes
Inger Johansson, Emmanouella M. Xanthopoulou, Yitian Zhou, Anabel Sanchez‐Spitman, Maaike van der Lee, Birgit M. Wollmann, Elisabet Størset, Jesse J. Swen, Henk‐Jan Guchelaar, Espen Molden, Marin M. Jukic, Magnus Ingelman‐Sundberg   +11 more
wiley   +1 more source

'Mostly women's issues' - Gender differences in community responses to a large-scale NGO programme to prevent violence against women in urban India. [PDF]

Womens Stud Int Forum
Paradkar S, Singh C, Suryavanshi A, Tiwari A, Cislaghi B, Daruwalla N, Osrin D, Gram L.   +7 more
europepmc   +1 more source

Crisis Management and Resilience Building Through the Women in Red Protest: The Handmaid's Tale Performances in Response to Israel's Judicial Overhaul

Conflict Resolution Quarterly, EarlyView.
ABSTRACT This paper examines the resilience building and public crisis management led by the “Building an Alternative” feminine NGO in Israel during the 2023 mass demonstrations against the judicial overhaul. The proposed judicial overhaul was perceived as a threat to both democratic foundations and women's rights in Israel.
Rachelly Ashwall‐Yakar, Oriana Abboud Armaly, Smadar Bracha, Hadar Hashash   +3 more
wiley   +1 more source

'Important, but difficult': Swedish primary care professionals' perceptions and experiences of dealing with violence against women: an interview study. [PDF]

BMC Prim Care
Öhman A, Vives-Cases C, Edin K.
europepmc   +1 more source

Social representations of violence against women in the nursing perspective [PDF]

, 2011
Sandra Maria Cezar Leal, Marta Júlia Marques Lopes, Filomena Gaspar   +2 more
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