Results 51 to 60 of about 91,050 (265)

Social network size and endorsement of political violence in the US

Injury Epidemiology
Background In recent years, the United States (US) has witnessed a rise in political violence. Prior research has found that an individual’s social network is associated with their likelihood of engaging in various forms of violence, but research on ...
Julia P. Schleimer, Paul M. Reeping, Sonia L. Robinson, Garen J. Wintemute   +3 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Public funds, public safety: a scoping review of government spending decisions and their impact on interpersonal violence and suicide

Injury Epidemiology
Objectives To conduct a scoping review of research on government spending and violence. Methods We searched nine databases for peer-reviewed publications evaluating the association between government spending on public goods and services and (other- or ...
Julia J. Lund, Julia P. Schleimer, Paul M. Reeping, Veronica A. Pear   +3 more
doaj   +1 more source

Replacement thinking, status threat, and the endorsement of political violence among non-Hispanic white individuals in the US: A cross-sectional study

Preventive Medicine Reports
Objective: This study investigates the association between replacement thinking, status threat perceptions, and the endorsement of political violence among non-Hispanic white adults in the United States. It explores how perceived threats to social status
Paul M. Reeping, Garen J. Wintemute, Sonia L. Robinson, Andrew Crawford, Elizabeth A. Tomsich, Veronica A. Pear   +5 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Predicting neighborhood-level violence from features of the physical and social environment with machine learning

Injury Epidemiology
Background Violence is a leading cause of death and disparity in the United States. Individuals’ physical and social environments can prevent or foster violence, but these complex milieus are challenging to model.
Veronica A. Pear, Colette Smirniotis, Rose M. C. Kagawa   +2 more
doaj   +1 more source

Edukasi Tentang Zero Tolerance Kekerasan Seksual Pada Masyarakat Sekitar Kampus ITB

Warta Pengabdian Andalas
Sejalan dengan amanat Permendikbudristek No. 30 Tahun 2021 tentang Pencegahan dan Penanganan Kekerasan Seksual (PPKS) dan Rencana Strategi ITB untuk melaksanakan transformasi berkelanjutan guna menggapai reputasi nasional dan dunia, kegiatan pengabdian ...
Pratiwi Wikaningtyas, Herlien Dwiarti Soemari, Irma Damajanti, Sylviana Maya Damayanti, Rr. Diah Asih Purwaningrum, Danial Danial, Dewi Rupiani, Fanty Handayani, Agustini Hidavat, Edwin Adi Nugroho, Zahra Salsabilla, Gaitsa Farah Zahira Putri, Melita Jenar Karenina, Bonifacius Perdana Tinton S   +13 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Using Participatory Learning and Action in a Community-Based Intervention to Prevent Violence Against Women and Girls in Mumbai’s Informal Settlements

International Journal of Qualitative Methods, 2020
For over 3 decades, participatory learning and action (PLA) techniques have been prominent in formative and evaluative studies in community-based development programs in the Global South.
Proshant Chakraborty, Nayreen Daruwalla, Apoorwa Deepak Gupta, Unnati Machchhar, Bhaskar Kakad, Shilpa Adelkar, David Osrin   +6 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source