Results 51 to 60 of about 4,740 (212)

“This program is literally saving lives”: A participatory qualitative study of youth outcomes in a community-based music program to interrupt violence

BMC Public Health
Introduction Despite urgent need for evidence-based violence prevention solutions, demonstrating the impact of community-based violence prevention programs, which are primed to be culturally relevant and community-tailored, remains difficult.
Hillary M. Kapa, Stephanie M. Garcia, Christopher Thornton, Matthew Kerr, Carolena Muno, Xadyah Holness, Aquil Shakur, Rachel K. Myers   +7 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Individual, firearm, and purchasing characteristics associated with risk of firearm-related violent crime arrest: a nested case-control study

Injury Epidemiology
Background Firearm purchasing records offer a potentially important administrative data source to identify individuals at elevated risk of perpetrating firearm violence.
Hannah S. Laqueur, Julia P. Schleimer, Aaron B. Shev, Rose Kagawa   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Predicting neighborhood-level violence from features of the physical and social environment with machine learning

Injury Epidemiology
Background Violence is a leading cause of death and disparity in the United States. Individuals’ physical and social environments can prevent or foster violence, but these complex milieus are challenging to model.
Veronica A. Pear, Colette Smirniotis, Rose M. C. Kagawa   +2 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Replacement thinking, status threat, and the endorsement of political violence among non-Hispanic white individuals in the US: A cross-sectional study

Preventive Medicine Reports
Objective: This study investigates the association between replacement thinking, status threat perceptions, and the endorsement of political violence among non-Hispanic white adults in the United States. It explores how perceived threats to social status
Paul M. Reeping, Garen J. Wintemute, Sonia L. Robinson, Andrew Crawford, Elizabeth A. Tomsich, Veronica A. Pear   +5 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Social network size and endorsement of political violence in the US

Injury Epidemiology
Background In recent years, the United States (US) has witnessed a rise in political violence. Prior research has found that an individual’s social network is associated with their likelihood of engaging in various forms of violence, but research on ...
Julia P. Schleimer, Paul M. Reeping, Sonia L. Robinson, Garen J. Wintemute   +3 more
doaj   +1 more source