Results 81 to 90 of about 4,740 (212)

Rates of out-of-home care among children in Canada: an analysis of national administrative child welfare data

Health Promotion and Chronic Disease Prevention in Canada
IntroductionAs a part of the public health approach to child welfare, data about children placed in out-of-home care are needed to assess population trends, understand drivers of social and health inequities, and examine outcomes for
Nathaniel J. Pollock, Alexandra M. Ouédraogo, Nico Trocmé, Wendy Hovdestad, Amy Miskie, Lindsay Crompton, Aimée Campeau, Masako Tanaka, Cindy Zhang, Claudie Laprise, Lil Tonmyr   +10 more
doaj   +1 more source

Using the PhotoStory Method to understand the cultural context of youth victimisation in the Punjab [PDF]

International Journal of Emotional Education, 2015
Bullying is an international issue that is only just beginning to be researched in India and anecdotal evidence in Punjab, India, has suggested that most schools in the Punjab are in denial about bullying on campus.
Grace Skrzypiec, Phillip Slee, Damanjit Sandhu   +2 more
doaj  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Neighborhood spikes in drug and alcohol overdoses and subsequent suicide: A serial cross-sectional study of California ZIP codes

Preventive Medicine Reports
Objective: The overdose crisis potentially increases risk factors for suicide while decreasing resources available to help those in need. This study sought to determine whether acute increases in drug or alcohol overdoses increase suicide rates. Methods:
Veronica A. Pear, Sonia L. Robinson, Julia P. Schleimer, Garen J. Wintemute, Aimée Moulin   +4 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Reducing violence and injury in the WHO European region

The Lancet Public Health, 2020
Yongjie Yon, Lucía Hernández-García, Gianluca Di Giacomo, Ivo Rakovac, Jonathon Passmore, Bente Mikkelsen   +5 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Violence – Prevention and Interventions

Panamerican Journal of Trauma, Critical Care & Emergency Surgery, 2023
Michel Aboutanos, Nicholas Thomson
openaire   +1 more source