Results 161 to 170 of about 2,347 (246)

A comprehensive molecular atlas of the mesenchymal cell types in the mouse liver. [PDF]

EMBO Rep
Pietilä R, Genové G, Mocci G, Miao Y, Liu J, Leptidis S, Del Gaudio F, Uhrbom M, Vázquez-Liébanas E, Gustafsson S, Buyandelger B, Raschperger E, Björkegren JLM, Hansson EM, Gaengel K, Mäe MA, Jeansson M, Vanlandewijck M, He L, Strell C, Peng XR, Lendahl U, Betsholtz C, Muhl L.   +23 more
europepmc   +1 more source

A Modular DNAzyme for Precise Visualization and Intervention of Alternative Splicing Isoforms in Live Cells

Advanced Science, EarlyView.
A Stringent dUPlex‐activated Error Robust (SUPER) DNAzyme system enables real‐time imaging of alternative mRNA splicing (e.g., Bcl‐xL/Bcl‐xS) in living cells via target‐triggered split‐DNAzyme reassembly and dual‐color fluorescence. It also achieves mRNA‐selective knockdown through DNAzyme‐based gene regulation, serving as a versatile tool for splicing
Mengru Lin, Jiale Sun, Yuqing Mao, Yuhao Tang, Fuan Wang, Zhihong Liu, Jing Wang   +6 more
wiley   +1 more source

<i>Echinococcus granulosus</i> antigen B ameliorates myocardial infarction through promoting M2 macrophage polarization. [PDF]

Front Cell Infect Microbiol
Zhang W, Liu B, Wang S, Xu X, Jin Q, Yang C, Wang H, Gao E, Zhan B, Wu S, Wang R, Zhou R, Yang X.   +12 more
europepmc   +1 more source

His‐MMDM: Multi‐Domain and Multi‐Omics Translation of Histopathological Images with Diffusion Models

Advanced Science, EarlyView.
His‐MMDM is a diffusion model‐based framework for scalable multi‐domain and multi‐omics translation of histopathological images, enabling tasks from virtual staining, cross‐tumor knowledge transfer, and omics‐guided image editing. ABSTRACT Generative AI (GenAI) has advanced computational pathology through various image translation models.
Zhongxiao Li, Tianqi Su, Bin Zhang, Wenkai Han, Sibin Zhang, Guiyin Sun, Yuwei Cong, Xin Chen, Jiping Qi, Yujie Wang, Shiguang Zhao, Hongxue Meng, Peng Liang, Xin Gao   +13 more
wiley   +1 more source

Single-cell analysis reveals T cell dysfunction driven by macrophages and differential expression of transposable elements in severe COVID-19 patients. [PDF]

Heliyon
Zhu A, Zhou L, Chen Z, Liu D, Feng H, Cai B, Chen X, Zhao J, Zhao J, Chen J, Li M, He J.   +11 more
europepmc   +1 more source

Machine Learning‐Enhanced Analysis of Exosomal Surface Sialic Acid Using Surface‐Enhanced Raman Spectroscopy for Ovarian Cancer Diagnosis and Therapeutic Monitoring

Advanced Science, EarlyView.
Machine learning‐assisted surface‐enhanced Raman spectroscopy analysis of exosomal sialic acid for ovarian cancer diagnosis, as well as independent monitoring of exosomal sialic acid expression levels across different treatment periods, reveals a potential correlation with treatment response.
Lili Cong, Jiaqi Wang, Sijun Huang, Xiaxia Man, Yi Guo, Shuping Xu, Songling Zhang   +6 more
wiley   +1 more source

SPOCK1 promotes the progression of breast cancer by modulating cancer-associated fibroblasts and exerts a synergistic effect with ANXA2. [PDF]

Front Oncol
Jie Y, Fei X, Fan M.
europepmc   +1 more source

The Reality of the Devil. [PDF]

, 1905
Carus, Paul
core   +1 more source

Multi‐Tissue Genetic Regulation of RNA Editing in Pigs

Advanced Science, EarlyView.
This study presents the first multi‐tissue map of RNA editing and its genetic regulation in pigs. By integrating RNA editing profiles, edQTL mapping, GWAS, and cross‐species comparisons, this work establishes RNA editing as a distinct regulatory layer linking genetic variation to complex traits, highlighting its functional and evolutionary significance.
Xiangchun Pan, Wentao Gong, Xiaodian Cai, Jinyan Teng, Jiali Cai, Haonan Zeng, Wondossen Ayalew, Qingpeng Shen, Zhanming Zhong, Yifei Wang, Wenjing Zhang, Yuhan Tian, Dantong Xu, Yahui Gao, Hongwei Yin, Yuebo Zhang, Jiahui Hou, Tianru Zhou, Jiaqi Li, Lingzhao Fang, Xiaolong Yuan, Zhe Zhang   +21 more
wiley   +1 more source

Single-cell RNA sequencing highlights a significant retinal Müller glial population in dry age-related macular degeneration. [PDF]

iScience
Zeng B, Zhang C, Liang Y, Huang J, Li D, Liu Z, Liao H, Yang T, Liu M, Zou C, Liu D, Qin B.   +11 more
europepmc   +1 more source