Results 101 to 110 of about 153,475 (260)
Advanced Science, EarlyView.Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin +20 more
wiley +1 more source
Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences
Advanced Science, EarlyView.This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu +7 more
wiley +1 more source
String Department Student Concert: "Violin Concerto Opulence", February 5, 1990 [PDF]
, 1990 This is the concert program of String Department Student Concert: "Violin Concerto Opulence" performance on Monday, February 5, 1990 at 8:30 p.m., at the Boston University Concert Hall, 855 Commonwealth Avenue, Boston, Massachusetts. Works performed were
School of Music, Boston University
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Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis
Advanced Science, EarlyView.Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang +9 more
wiley +1 more source
, 1994 1.1. hegedűverseny : Op.post. Sz.36 (1907-08) = Concerto for violin and orchestra No.1 +2.2. hegedűverseny : Sz.112 (1937-38) = Concerto for violin and orchestra No.
Bartók Béla
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, 2021 PROGRAM: Violin Concerto No. 2 in D Minor, Op. 22 / Henryk Wieniawski -- Violin Concerto No. 3 in G Major, K. 216 / Wolfgang Amadeus Mozart -- Violin Concerto in E Minor, Op.
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Advanced Science, EarlyView.ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao +5 more
wiley +1 more source
Molly Hickey's MM Violin Recital 2
, 2019 Sonata for Solo Violin in D Major, Op. 115 by Sergei Prokofiev Omagiu for Violin and Piano by Matthew O’Neill Violin Concerto in E Minor, Op. 64 by Felix Mendelssohn Fratres for Violin and Piano by Arvo PärtRelated performance for this degree -- Molly ...
Hickey, Molly
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Advanced Science, EarlyView.The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang +11 more
wiley +1 more source
Advanced Science, EarlyView.A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait +7 more
wiley +1 more source