Results 151 to 160 of about 35,241 (272)

Gaps in Community-Based Screening for Non-Communicable Diseases in Saudi Arabia. [PDF]

Diseases
Al Ghareeb G, Alkhair ZM, Alradwan Z, Alqaissoom H, Soumel HA, Alsaffar KR, Muhaimeed F, Alsaihati B, Alkhrayef MN, Alradwan I.   +9 more
europepmc   +1 more source

Public works, private spaces : Mozart opera in the Lobkowitz theatres in Bohemia [PDF]

, 2008
Libin, Kathryn
core  

The FOXC2‐LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell Carcinoma

Advanced Science, EarlyView.
Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao, Tong Xu, Chengyuan Wang, Chenyuan Wang, Junfeng Xie, Rui Zheng, Ke Wang, Xingzuo Jiang, Zewei Hu, Hongwei Jing, Lin Li, Tao Liu   +11 more
wiley   +1 more source

Salidroside Alleviates Renal Ischemia-reperfusion Injury by Inhibiting Macrophage Pyroptosis Through HIF Signaling. [PDF]

Inflammation
Xueqiang Z, Yu Z, Wendong L, Shuying F, Jie H.   +4 more
europepmc   +1 more source

Targeting the GPX4–FUNDC1 Interaction with Magnesium Lithospermate B Attenuates Sepsis‐Associated Lung Injury

Advanced Science, EarlyView.
The diagram depicts the endothelial‐protective mechanism of magnesium lithospermate B (MLB) in sepsis‐associated lung injury. MLB binds GPX4 at Gly79, disrupts its interaction with FUNDC1, prevents mitophagy‐mediated GPX4 degradation, restores mitophagic flux, reduces ROS, and limits ferroptosis.
Zhixi Li, Chang Liu, Zhaoxue Ma, Dongyou Zheng, Renkai Wang, Yongjing Yu, Guangmin Chen, Chenglong Li, Yue Bu, Hang Cao, Bing Zhang   +10 more
wiley   +1 more source

Single-cell mRNA analysis and surface marker expression profiling of circulating immune cells in humans with alpha-gal syndrome. [PDF]

Front Immunol
Choudhary SK, Commins SP.
europepmc   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

Scale up manufacturing approach for production of human induced pluripotent stem cell-derived islets using Vertical Wheel® bioreactors. [PDF]

NPJ Regen Med
Dadheech N, Bermúdez de León M, Czarnecka Z, Cuesta-Gomez N, Jasra IT, Pawlick R, Marfil-Garza B, Sapkota S, Verhoeff K, Razavy H, Anwar P, Singh A, Ray N, O' Gorman D, Jickling G, Lyon J, MacDonald P, Shapiro AMJ.   +17 more
europepmc   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Intestinal stem and progenitor cells exhibit distinct adaptive responses to inflammatory stress in IBD. [PDF]

Stem Cell Res Ther
Balasubramanian B, Patel S, Gall L, Hannan NRF, Dalleywater W, Huelsken J, Pin C, Moran GW, Ordóñez-Morán P.   +8 more
europepmc   +1 more source