Results 181 to 190 of about 35,241 (272)

Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1+ Macrophages to Foster Liver Metastasis, Targeted by Indole‐3‐Acetic Acid

Advanced Science, EarlyView.
Cytoplasmic RNF32 fuels CRC liver metastasis by degrading GSK3β, which stabilizes β‐catenin and activates Wnt/EMT. Moreover, RNF32 rewires the metastatic niche: it depletes CD8+/CD4+ T and NK cells while recruiting SPP1+ macrophages (which boost tumor stemness via CD44), fibroblasts, and immunosuppressive monocytes to aid colonization.
Hongyu Wang, Shipeng Dai, Yuchen Xie, Pengyu Chen, Yue Chai, Chongyu Wang, Xueying Huang, Xiao Dong, Junfeng Shi, Yongxiang Xia, Xiaofeng Qian, Weiwei Tang, Yichan Zhou   +12 more
wiley   +1 more source

Are We Getting Better? Trends in 30-Day Readmission and Length of Stay Following Hip Fracture Surgery Among Older Adults: A Five-Year ACS-NSQIP Analysis. [PDF]

Geriatr Orthop Surg Rehabil
Twomey-Kozak J, Atwater JL, Taylor KA, DeBaun M, Pean CA.   +4 more
europepmc   +1 more source

A Shear Thickening Colloidal Suspension Functioning via Progressive Impact Jamming with Persistent Lubrication Layer

Advanced Science, EarlyView.
An ionic liquid‐based shear‐thickening fluid (ILSTF) exhibits lubricated dynamics from strong shear thickening to impact‐triggered jamming. A persistent nanometric solvation layer around silica governs both the shear thickening saturation in rheology and jamming front propagation under dynamic impact compression.
Yiran Wu, Yifeng Yu, Yiqiu Zhao, Qin Xu, T. X. Yu, Xin Zhang, Jinglei Yang   +6 more
wiley   +1 more source

Exploring the meta-motivational strategies utilized by medical students in Jordan: an exploratory study. [PDF]

BMC Med Educ
Murshidi R, Abdallat M, Hammouri M, Al-Huneidy R, Alenezi K, Alrajehi A, Al-Mutairi N, Alkanderi W, Alkandari A, Aldousari A, Alenezi S, Taleb A, Alzalzaleh S, Alkayal A, Taha H, Al-Ani A.   +15 more
europepmc   +1 more source

Inactivation Rap2a in Endothelial Cell Prevents Pulmonary Fibrosis by Regulating Immune Microenvironment Through MAP4K4‐VCAM1 Signaling

Advanced Science, EarlyView.
We identified the endothelial RAP2A as a regulator of inflammatory endothelial activation in experimental lung fibrosis and suggest that targeting RAP2A‐mediated signaling may represent a potential strategy to modulate endothelial–immune crosstalk during fibrotic lung injury.
Xiaolan Zheng, Peng Yue, Kaiyu Zhou, Guidong Gong, Yue Zhang, Sha Lin, Xu Liu, Yanjiang Zheng, Siyuan Jing, Junling Guo, Yan Qi, Bi‐Sen Ding, Yimin Hua, Yifei Li   +13 more
wiley   +1 more source

Pareto-based design of thermophotovoltaic micro-combustors via a novel framework combining IGWO-tuned ANN, multi-objective multi-verse optimization, and ARAS-based decision making. [PDF]

Sci Rep
Alawad MA, Omar I, Alizadeh A, Shaban M, Sadeq AM, Singh Sawaran Singh N, Louhichi B, Mostafa L.   +7 more
europepmc   +1 more source

Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes

Advanced Science, EarlyView.
Testicular endothelial cells (TECs) function as central signaling hubs that coordinate interstitial homeostasis. Diabetes disrupts TEC‐derived PDGF signaling, silences the JUND‐MCL1 survival program in Leydig cells, and impairs peritubular function, leading to fibrosis and testosterone insufficiency.
Wenxiu Zhang, Kai Hong, Yanling Tang, Lina Cui, Xiaojian Lu, Jianxing Cheng, Yangyi Fang, Qiaoling Jiang, Ziyan Zhuang, Songzhan Gao, Hui Jiang, Qiang Liu, Jingtao Guo, Zhe Zhang, Xiaoyan Wang   +14 more
wiley   +1 more source

Snowmelt runoff model (SRM) for regulated watersheds with regulation-correction. [PDF]

Appl Water Sci
Bhagwat N, Zhou X, Nagisetty R, Jiang L, Shaw G, Apple M, Clotfelter J.   +6 more
europepmc   +1 more source

SAGE: Spatially Aware Gene Selection and Dual‐View Embedding Fusion for Domain Identification in Spatial Transcriptomics

Advanced Science, EarlyView.
SAGE is a unified framework for spatial domain identification in spatial transcriptomics that jointly models tissue architecture and gene programs. Topic‐driven gene selection (NMF plus classifier‐based scoring) highlights spatially informative genes, while dual‐view graph embedding fuses local expression and non‐local functional relations.
Yi He, Yunpei Xu, Liqing Ding, Hong‐Dong Li, Yaohang Li, Shaokai Wang   +5 more
wiley   +1 more source

Performance of a self-developed panel for biogeographic ancestry inference and dissection of the genetic background of three Tibetan groups. [PDF]

Hereditas
Lin Y, Yuan X, Wang X, Li S, Yao H, Dong B, Zhu B.   +6 more
europepmc   +1 more source