Results 171 to 180 of about 2,913,940 (309)

Enteric Viral Pathogens in Infants in the United States: 2017-2020. [PDF]

Pediatrics
Cannon JL, Baker JM, Mattison CP, Browne H, Nguyen K, Burke RM, Mijatovic-Rustempasic S, Casey-Moore MC, Gautam R, Bartlett E, Embury S, Burrell A, Conrey S, Parashar UD, Payne DC, Staat MA, Morrow AL, Vinjé J.   +17 more
europepmc   +1 more source

Macrophage Immune Responses in Viral Infections: Functional Plasticity and Therapeutic Targeting. [PDF]

J Microbiol Biotechnol
Kim J, Lee H, Jang YS.
europepmc   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Impact of Sex on Viral Shedding and Symptom Severity During Acute COVID-19. [PDF]

Pathog Immun
Kung E, Deo R, Choudhary MC, Chew KW, Evering TH, Ignacio RB, Jagannathan P, Flynn JP, Regan J, Moser C, Giganti MJ, Hughes MD, Ritz J, Javan AC, Greninger AL, Singh U, Fischer W, Daar ES, Wohl DA, Eron JJ, Currier JS, Coombs RW, Smith DM, Li JZ, ACTIV-2/A5401 Study Team.   +24 more
europepmc   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Repurposed Medicines for Viruses With Epidemic or Pandemic Potential: A Horizon Scan. [PDF]

Pharmacol Res Perspect
Akinbolade S, Potter R, Inskip A, Nesworthy J, Brock K, Norman G.   +5 more
europepmc   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Editorial: Viral surface spikes: host cell entry, immune responses and evasion, and implications for viral infection, inhibition and rebound. [PDF]

Front Immunol
Gobeil SM, Lu M, Sharma A.
europepmc   +1 more source

Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez, Monica Ferrer Socorro, Kathryn Yang, Nicole Battaglia, Zainab Zaman, Mariko Bennett, Adeline Vanderver, Pui Y. Lee, Lauren A. Henderson, Milena M. Andzelm, Darius Ebrahimi‐Fakhari   +10 more
wiley   +1 more source

Translational repression of viral RNAs supports persistent arbovirus infection in mosquitoes. [PDF]

PLoS Biol
Talló-Parra M, Puig-Torrents M, Pérez-Vilaró G, Ribó Pons S, Díez J.   +4 more
europepmc   +1 more source