Results 211 to 220 of about 6,506,858 (262)

Correction: Novel factors to predict respiratory viral disease progression in allogeneic hematopoietic cell transplant recipients. [PDF]

Bone Marrow Transplant
Ogimi C, Xie H, Waghmare A, Jerome KR, Leisenring WM, Ueda Oshima M, Carpenter PA, Englund JA, Boeckh M.   +8 more
europepmc   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Exogenous dsRNA-Mediated RNAi: Mechanisms, Applications, Delivery Methods and Challenges in the Induction of Viral Disease Resistance in Plants. [PDF]

Viruses
Venu E, Ramya A, Babu PL, Srinivas B, Kumar S, Reddy NK, Babu YM, Majumdar A, Manik S.   +8 more
europepmc   +1 more source

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source

Tanzania's first Marburg Viral Disease outbreak response: Describing the roles of FELTP graduates and residents. [PDF]

PLOS Glob Public Health
Hussein AK, Kishimba RS, Simba AA, Urio LJ, Lema NA, Mmbaga VM, Mutayoba BK, Malugu NE, Leonard D, Hokororo J, Kelly ME, Paschal A, Ngenzi D, Hellar JA, Kauki GC, Saguti GE, Yoti Z, Mukurasi KI, Mponela M, Mgomella GS, Gatei W, Kaniki I, Swaminathan M, Kwesi EM, Nagu TJ.   +24 more
europepmc   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Viral disease outcomes are indistinguishable between experimentally infected bats and rodents

Farrell MJ, Tucker SK, Mollentze N, Streicker DG.   +3 more
europepmc   +1 more source

Community perspectives of Ebola Viral Disease in high-risk transmission border regions of Tanzania: a qualitative inquiry. [PDF]

BMC Public Health
Metta E, Mohamed H, Kusena P, Nyamhanga T, Bahuguna S, Kakoko D, Siril N, Araya A, Mwiru A, Magesa S, Makene L, Rwechungura A, Kirakoya FB, Kazaura M, Frumence G.   +14 more
europepmc   +1 more source

Compensatory Mitophagy via NEDD4/HIF‐1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα

Advanced Science, EarlyView.
The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Dengyuan Feng, Qinghuan Shen, Junqi Zhang, Jiawen Liu, Zeping Gui, Zijie Wang, Qianguang Han, Shuang Fei, Hao Chen, Li Sun, Jun Tao, Zhijian Han, Xiaobing Ju, Min Gu, Jianjian Zhang, Ruoyun Tan   +15 more
wiley   +1 more source

Exosome-mediated regulation of inflammatory pathway during respiratory viral disease. [PDF]

Virol J
Gheitasi H, Sabbaghian M, Shekarchi AA, Mirmazhary AA, Poortahmasebi V.   +4 more
europepmc   +1 more source