Results 211 to 220 of about 4,114,474 (307)

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Loop-Mediated Isothermal Amplification (LAMP) for the Diagnosis of High-Burden Viral Diseases in Resource-Limited Countries. [PDF]

Pathogens
Vasconcelos-Martins AC, Giovanetti M, Elias MC, Slavov SN, Sampaio SC.   +4 more
europepmc   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

PROTACs in the treatment of viral diseases. [PDF]

Future Med Chem
Bhole RP, Kute P, Gurav SS.
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Advances in CRISPR-Cas12a/13a-Based Nucleic Acid Detection for Porcine Viral Diseases: A Comprehensive Review. [PDF]

Vet Sci
Zhang X, Zhao X, Song Y, Luo Y, Yao L, Wu Q, Ye T, Liang W, Zhang X, Liang Y, Liang B, Zhang J, Li X.   +12 more
europepmc   +1 more source

CNTN2 Deficiency Disrupts Ascending Auditory Neuroglial Interactions and Redox Homeostasis in Neural Presbycusis

Advanced Science, EarlyView.
. ABSTRACT Neural presbycusis disrupts auditory timing and speech perception, yet its molecular basis remains poorly understood. This study identifies Cntn2 as the Ranvier's nodal molecule significantly downregulated in aged auditory nerves. Cntn2 heterozygous knockout (Cntn2+/−) mice showed elevated auditory brainstem response thresholds and prolonged
Penghui Chen, Jingyi Zhu, Sihan Huang, Beibei Xu, Maoli Duan, Jingrong Lv, Jiarui Chen, Jun Yang, Shule Hou   +8 more
wiley   +1 more source

Different SARS-CoV-2 Subvariants and Coagulation Markers Trend: A Retrospective Multicentric Study From Iranian Network for Research in Viral Diseases (INRVD). [PDF]

Health Sci Rep
Razavi A, Koltapeh MP, Nazari T, Morvaridi A, Banivaheb B, Saeb S, Moulaeian M, Zakaryaei A, Sabzalian A, Raei M, Razavi B, Motlaghzadeh S, Hosseini SS, Karami H, Ghafari P, Aboofazeli A, Nastarvand S, Sarabi NKN, Avakian A, Ebadinejad S, Keyhani T, Danafar P, Rahimlou R, Heidarian S, Mondeali M, Nafe-Monfared F, Jafarpour M, Samiee M, Birang F, Mirzazadeh A, Abadi SAF, Barkhordari K, Siavoshi S, Biklari M, Khodabakhsh M, Javadi A, Mirzaee S, Didgar F, Etebari M, Soltanmohamad S, Shahbaz B, Kord E, Shahri SMH, Ebrahimzade M, Moghaddam AA, Sanavi FS, Moattari A, Edalat F, Sheijani MF, Moghadami M, Yaghubi T, Mojtahedi A, Heidarzadeh A, Naghipour M, Luyeh MS, Nazemi P, Alipasandi K, Albaji M, Afzali M, Shokouhi N, Ezani A, Najari HR, Hosseini M, Ghobadi A, Momeni A, Fattahi SZ, Mohsenzadeh M, Jafari M, Azizi A, Pouryousef S, Tabarraei A, Moradi A, Azimi S, Yahyapour Y, Bayani M, Poortahmasebi V, Varshochi M, Ziaee M, Ghafari S, Javanmard D, Soleimani A, Mozhgani SH, Mokhames Z, Akhoundimeybodi Z, Astani A, Abdollahi A, Hadadi A, Salehi MR, Hajiabdolbaghi M, Raeeskarami SR, Kafan S, Montazeri M, Pazoki M, Riahi T, Talebi-Taher M, Ataei-Pirkooh A, Bokharaei-Salim F, Faiz SHR, Kalantari S, Yasin Z, Jazayeri SM.   +100 more
europepmc   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Host centric drug repurposing for viral diseases. [PDF]

PLoS Comput Biol
de Siqueira Santos S, Yang H, Galeano A, Paccanaro A.   +3 more
europepmc   +1 more source