Results 241 to 250 of about 3,561,289 (310)

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Intelligent Patient Management in Viral Diseases: An Integrated Regression Model and Multi-Criteria Decision-Making Approach to Convalescent Plasma Transfusion. [PDF]

Healthcare (Basel)
Mohammed TJ, Albahri AS, Alnoor A, Khaw KW, Chew XY, Lim ST.   +5 more
europepmc   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Editorial: Innovative strategies for enhancing crop resilience against plant viral diseases. [PDF]

Front Plant Sci
Padmanabhan C.
europepmc   +1 more source

Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing

Advanced Science, EarlyView.
An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, Otto Kollmar, Mairene Coto‐Llerena, Luca Di Tommaso, Visar Vela, Lukas Bubendorf, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio   +17 more
wiley   +1 more source

Tetramycin ameliorates tebuconazole·azoxystrobin to control leaf spot and viral diseases of Taizishen. [PDF]

Front Plant Sci
Tian B, Tang C, Liu J, Jin B, Zhang C.
europepmc   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Differences in concentration of neuron-specific enolase (NSE), neutrophil elastase (NE), and calcium-binding protein S100B in viral diseases: a pilot study focused on normoglycemic COVID-19 patients. [PDF]

Front Mol Biosci
Adamiec-Mroczek J, Bronowicka-Szydełko A, Lewandowski Ł, Nowak B, Turno-Kręcicka A, Misiuk-Hojło M, Stanek M, Matera-Witkiewicz A, Krupińska M, Gostomska-Pampuch K, Kuźnik E, Rabczyński M, Matusiewicz M, Berdowska I, Korbecka M, Mykhailova D, Przystupa Z, Smyk B, Wojakowska A, Amedei A, Trocha M, Madziarska K.   +21 more
europepmc   +1 more source

Next-Generation Vaccines and Antiviral Platforms: Molecular Advancements in the Struggle against Emerging Zoonotic and Viral Diseases. [PDF]

Arch Razi Inst
Abdol Ghaffar E, Zeliha S, Hamdia Yousif I, Elifsena Canan AA, Shahid A.   +4 more
europepmc   +1 more source

Monitoring of Selected Swine Viral Diseases in Peruvian Amazon Peccaries. [PDF]

Ecohealth
Menajovsky MF, Mayor P, Bodmer R, Pérez-Peña P, Ulloa GM, Greenwood AD, Montero S, Lescano AG, Santolalla ML, Segalés J, Sibila M, Cabezón O, Espunyes J.   +12 more
europepmc   +1 more source