Results 151 to 160 of about 3,311,882 (262)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Viral hepatitis surveillance United States, 2017 [PDF]

Each week, health departments report cases of hepatitis A, hepatitis B, and hepatitis C to the Centers for Disease Control and Prevention (CDC) through the National Notifiable Diseases Surveillance System (NNDSS).

core  

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Molecular epidemiological surveillance of the feline coronavirus reveals novel recombinant FCoV strains with evidence of ongoing viral evolution. [PDF]

Virus Res
Shah AU, Vagra C, Moawad N, Rosen M, Levitan D, Hemida MG.   +5 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Prolonged SARS-CoV-2 infection in hematologic malignancies: clinical impact, risk factors and intra-host viral evolution. [PDF]

Front Immunol
Jiménez M, Andrés C, González-Sánchez A, Navarro V, Medina I, Prats-Méndez I, Antón A, Martinez-Gallo M, Albasanz A, Arenas P, Pérez A, Novoa S, Serna Á, Pumarola T, Hernández M, Ruiz-Camps I, Valcárcel D, Crespo M, Esperalba J, Bosch F, Abrisqueta P.   +20 more
europepmc   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

A combination of broadly neutralizing antibodies prevents in vitro SHIV162p3 cell-free transmission more efficiently than cell to cell transmission

Journal of Virus Eradication, 2016
K. Suphaphiphat, M. Tolazzi, G. Scarlatti, R. Legrand, M. Cavarelli   +4 more
doaj   +1 more source

African swine fever in the era of global expansion: Epidemiology, transmission dynamics, viral evolution, and One Health control strategies. [PDF]

Vet World
Bie J.
europepmc   +1 more source

Intrinsic factors driving mosquito vector competence and viral evolution: a review. [PDF]

Front Cell Infect Microbiol, 2023
Lewis J, Gallichotte EN, Randall J, Glass A, Foy BD, Ebel GD, Kading RC.   +6 more
europepmc   +1 more source