Results 151 to 160 of about 238,327 (306)

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

The Hepatitis C virus : your part in its downfall : getting to know the virus and its host [PDF]

, 2005
The cloning of the genome of the Hepatitis C virus (HCV) in 1989 provided sensitive screening tools and specific diagnostic assays which helped health workers to limit viral spread and scientists to design effective anti-viral agents.
Pullicino, Edgar
core  

Unique features of HLA-mediated HIV evolution in a Mexican cohort: a comparative study

, 2009
Background: Mounting evidence indicates that HLA-mediated HIV evolution follows highly stereotypic pathways that result in HLA-associated footprints in HIV at the population level.
Santiago Avila-Rios, Avila-Rios, S., Brumme, Z.L., Espinosa Enrique, Carlson, J.M., Valenzuela-Ponce Humberto, Carlson Jonathan M, John Mina, Ormsby Christopher E, David Heckerman, Heckerman, D., Juan Blanco-Heredia, Blanco-Heredia Juan, Mallal Simon, Brumme Zabrina L, Daniela Garrido-Rodriguez, Espinosa, E., Enrique Espinosa, Reyes-Teran Gustavo, Garrido-Rodriguez, D., Ormsby, C.E., Valenzuela-Ponce, H., Garcia-Morales Claudia, Zabrina L Brumme, John, M., Heckerman David, Simon Mallal, Gustavo Reyes-Teran, Claudia Garcia-Morales, Christopher E Ormsby, Humberto Valenzuela-Ponce, Garrido-Rodriguez Daniela, Avila-Rios Santiago, Mina John, Garcia-Morales, C., Jonathan M Carlson, Reyes-Teran, G., Blanco-Heredia, J., Mallal, S.   +38 more
core   +1 more source

Nonconserved epitopes dominate reverse preexisting T cell immunity in COVID-19 convalescents

Signal Transduction and Targeted Therapy
The herd immunity against SARS-CoV-2 is continuously consolidated across the world during the ongoing pandemic. However, the potential function of the nonconserved epitopes in the reverse preexisting cross-reactivity induced by SARS-CoV-2 to other human ...
Xin Wang, Jie Zhang, Maoshun Liu, Yuanyuan Guo, Peipei Guo, Xiaonan Yang, Bingli Shang, Min Li, Jinmin Tian, Ting Zhang, Xi Wang, Ronghua Jin, Jikun Zhou, George F. Gao, Jun Liu   +14 more
doaj   +1 more source

Integrated Analysis of the 2022 SARS-CoV-2 Omicron Lineage Replacement Dynamics in Connecticut, US

Viruses
In 2022, consecutive sweeps of highly transmissible SARS-CoV-2 Omicron-derived lineages (B.1.1.529*) maintained viral transmission despite extensive antigen exposure from both vaccinations and infections. To better understand Omicron variant emergence in
Nicholas F. G. Chen, Kien Pham, Chrispin Chaguza, Rafael Lopes, Fayette Klaassen, Chaney C. Kalinich, Yale SARS-CoV-2 Genomic Surveillance Initiative, Nicholas Kerantzas, Sameer Pandya, David Ferguson, Wade Schulz, Daniel M. Weinberger, Virginia E. Pitzer, Joshua L. Warren, Nathan D. Grubaugh, Anne M. Hahn   +15 more
doaj   +1 more source

The Cellular Origins of Viral Evolution

Viruses lack the transcriptional machinery necessary to produce their own structural components. A key question, therefore, is how the first viral structures could form without this machinery. The answer is that the human genome contains the complete genetic blueprint for certain viruses.
openaire   +2 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Biodiversity and distribution of polar freshwater DNA viruses

, 2015
Viruses constitute the most abundant biological entities and a large reservoir of genetic diversity on Earth. Despite the recent surge in their study, our knowledge on their actual biodiversity and distribution remains sparse.
López-Bueno, Alberto, Pearce, David, Pearce, David A., Alcamí, Antonio, Aguirre de Cárcer, Daniel   +4 more
core   +1 more source