Results 181 to 190 of about 3,800,153 (377)

Evolution of CD8+ T Cell Immunity and Viral Escape Following Acute HIV-1 Infection [PDF]

, 2003
Jianhong Cao, John McNevin, Uma Malhotra, M. Juliana McElrath   +3 more
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Engineering a serum-resistant and thermostable vesicular stomatitis virus G glycoprotein for pseudotyping retroviral and lentiviral vectors. [PDF]

, 2013
Vesicular stomatitis virus G glycoprotein (VSV-G) is the most widely used envelope protein for retroviral and lentiviral vector pseudotyping; however, serum inactivation of VSV-G pseudotyped vectors is a significant challenge for in vivo gene delivery ...
Hwang, B-Y, Schaffer, DV
core  

HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants [PDF]

, 2005
Víctor Sánchez-Merino, Siwei Nie, Katherine Luzuriaga   +2 more
openalex   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Molecular studies on a complex of potyviruses infecting solanaceous crops, and some specific virus-host interactions [PDF]

, 2003
This thesis constitutes a comprehensive analysis of the molecular and biological characteristics of three potyviruses (genus Potyvirus, family Potyviridae) naturally occurring in cultivated and wild species of family Solanaceae: Peru tomato virus (PTV ...
Spetz, Carl
core  

Effect of human behavior on the evolution of viral strains during an epidemic [PDF]

, 2021
Asma Azizi, Natalia L. Komarova, Dominik Wodarz   +2 more
openalex   +1 more source

Nonconserved epitopes dominate reverse preexisting T cell immunity in COVID-19 convalescents

Signal Transduction and Targeted Therapy
The herd immunity against SARS-CoV-2 is continuously consolidated across the world during the ongoing pandemic. However, the potential function of the nonconserved epitopes in the reverse preexisting cross-reactivity induced by SARS-CoV-2 to other human ...
Xin Wang, Jie Zhang, Maoshun Liu, Yuanyuan Guo, Peipei Guo, Xiaonan Yang, Bingli Shang, Min Li, Jinmin Tian, Ting Zhang, Xi Wang, Ronghua Jin, Jikun Zhou, George F. Gao, Jun Liu   +14 more
doaj   +1 more source

Integrated Analysis of the 2022 SARS-CoV-2 Omicron Lineage Replacement Dynamics in Connecticut, US

Viruses
In 2022, consecutive sweeps of highly transmissible SARS-CoV-2 Omicron-derived lineages (B.1.1.529*) maintained viral transmission despite extensive antigen exposure from both vaccinations and infections. To better understand Omicron variant emergence in
Nicholas F. G. Chen, Kien Pham, Chrispin Chaguza, Rafael Lopes, Fayette Klaassen, Chaney C. Kalinich, Yale SARS-CoV-2 Genomic Surveillance Initiative, Nicholas Kerantzas, Sameer Pandya, David Ferguson, Wade Schulz, Daniel M. Weinberger, Virginia E. Pitzer, Joshua L. Warren, Nathan D. Grubaugh, Anne M. Hahn   +15 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source