Advanced Functional Materials, EarlyView.Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley +12 more
wiley +1 more source
BMC Research NotesObjective The aim of this study was to determine CD4 cell count and viral load count association and its joint clinical risk factors among adult TB/HIV co-infected patients.
Nurye Seid Muhie, Awoke Seyoum Tegegne
doaj +1 more source
Advanced Functional Materials, EarlyView.FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu +5 more
wiley +1 more source
Prevalence and risk factors of detectable HIV viral load among pregnant women with HIV infection seeking antenatal care in Southern Malawi [PDF]
Felix A. Mkandawire +7 more
openalex +1 more source
Evaluasi Viral Load HCV RNA 12 Minggu Post Terapi Sebagai Respons Keberhasilan Regimen Direct Acting Antiviral Pada Pasien Hepatitis C Di RSUD Dr. Soetomo Surabaya [PDF]
, 2020 Muhammad Faiz Awwaluddin Al-Mubarok
openalex
Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models
Advanced Functional Materials, EarlyView.Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen +30 more
wiley +1 more source
Feline herpesvirus 1 viral load related to environmental factors in sheltered cats
Ciência Rural: Shelter environment stress factors are related to FHV-1 viral reactivation. However, comparisons between conjunctival viral load and environmental factors have not been commonly evaluated.
Natasha Baumworcel +5 more
doaj +1 more source
The effects of an HIV‐1 immunogen (Remune) on viral load, CD4 cell counts and HIV‐specific immunity in a double‐blind, randomized, adjuvant‐controlled subset study in HIV infected subjects regardless of concomitant antiviral drugs [PDF]
, 2001 J R Turner +12 more
openalex +1 more source
Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System
Advanced Functional Materials, EarlyView.A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim +4 more
wiley +1 more source
Inactivating SARS‐CoV‐2 Virus with MOF‐Composites as Smart Face Masks
Advanced Functional Materials, EarlyView.In situ preparation and functionalization of MOF@Cotton fabrics as smart face masks for the immobilization of proteins and inactivation viruses, such as SARS‐CoV‐2. Abstract The significant impact of the SARS‐CoV‐2 (COVID‐19) pandemic outbreak on people's lives has highlighted the urgent need for effective personal protective equipment.
Romy Ettlinger +9 more
wiley +1 more source