Results 161 to 170 of about 3,712,649 (404)
Systematic review of the accuracy of plasma preparation tubes for HIV viral load testing.
PLoS ONE, 2019 Expanding access to HIV viral load testing is essential to improving the care and treatment of people living with HIV/AIDS and ending the AIDS epidemic. Though significant investments have been made in the past five years, many high burden, low resource ...
Robert Luo +3 more
doaj +1 more source
A simulation model for longitudinal HIV viral load and mother-to-child-transmission in pregnant and postpartum women [PDF]
arXiv, 2019 This manuscript describes the model specification, including input and output measures, dependencies, and structure for VLSiM-PPW, a Monte Carlo type model for HIV adherence, viral load and vertical transmission in pregnant and breastfeeding women.
arxiv
Within host dynamics of SARS-CoV-2 in humans: Modeling immune responses and antiviral treatments [PDF]
arXiv, 2020 In December 2019, a newly discovered SARS-CoV-2 virus was emerged from China and propagated worldwide as a pandemic. In the absence of preventive medicine or a ready to use vaccine, mathematical models can provide useful scientific insights about transmission patterns and targets for drug development.
arxiv
FEBS Open Bio, EarlyView.In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley +1 more source
The contribution of viral genotype to plasma viral set-point in HIV infection.
PLoS Pathogens, 2014 Disease progression in HIV-infected individuals varies greatly, and while the environmental and host factors influencing this variation have been widely investigated, the viral contribution to variation in set-point viral load, a predictor of disease ...
Emma Hodcroft +9 more
doaj +1 more source
FEBS Open Bio, EarlyView.The K+‐Cl− cotransporters (KCCs) facilitate the symport of ions across the plasma membrane. They participate in physiological processes including neuronal regulation. Here, we characterized KCCs from Drosophila and Hydra vulgaris. Comparative analyses of transporters provide insights into the mechanism of KCC ion transport, regulation, and evolution ...
Satoshi Fudo +4 more
wiley +1 more source
HIV Viral Load Monitoring in Resource-Limited Regions: Optional or Necessary? [PDF]
, 2017 Although it is a standard practice in high-income countries, determination of the human immunodeficiency virus (HIV) load is not recommended in developing countries because of the costs and technical constraints.
Calmy, Alexandra +8 more
core
Cost-effectiveness of point-of-care viral load monitoring of antiretroviral therapy in resource-limited settings: mathematical modelling study [PDF]
, 2013 Monitoring of HIV viral load in patients on combination antiretroviral therapy (ART) is not generally available in resource-limited settings. We examined the cost-effectiveness of qualitative point-of-care viral load tests (POC-VL) in sub-Saharan ...
Barth +30 more
core +2 more sources
FEBS Open Bio, EarlyView.Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley +1 more source