Results 171 to 180 of about 253,930 (319)

Hydroxyapatite Binding Peptide Lipid Nanoparticles for Biomimetic mRNA Delivery to Bone

Advanced Therapeutics, EarlyView.
Targeted delivery of therapeutic mRNA to peripheral tissues, including bone, is currently challenging. In the current work, a hydroxyapatite binding peptide (HABP) is conjugated to mRNA lipid nanoparticles (LNPs). HABP‐LNPs delivered systemically are demonstrated to reduce transfection in the liver and improve transfection in the femurs of mice ...
Joshua A. Choe, Jena E. Moseman, Jamie M. Jones, Jacobus C. Burger, Ashley M. Weichmann, Douglas G. McNeel, William L. Murphy   +6 more
wiley   +1 more source

Determinants of viral load suppression among adolescents on antiretroviral therapy in Eswatini: a cross-sectional study. [PDF]

BMC Infect Dis
Hlophe LD, Shumba CS, Bedada DT, Nyasulu PS.   +3 more
europepmc   +1 more source

Immune activation and plasma viral load in HIV-infected African individuals

, 1999
John R. Dyer, Irving Hoffman, Joseph J. Eron, Susan A. Fiscus, Myron S. Cohen   +4 more
openalex   +1 more source

Residual Low-Level Viral Replication Could Explain Discrepancies between Viral Load and CD4+ Cell Response in Human Immunodeficiency Virus—Infected Patients Receiving Antiretroviral Therapy [PDF]

, 2000
Felipe García, Carmen Vidal, Montserrat Plana, Anna Cruceta, Marta Gallart, Tomàs Pumarola, José M. Miró, José M. Gatell   +7 more
openalex   +1 more source

Opportunities in Therapeutic mRNA Stabilization: Sequence, Structure, Adjuvants and Vectors

Advanced Therapeutics, EarlyView.
Current mRNA lipid nanoparticles rely on cold storage, which increases the cost and reduces access to the vaccines. As mRNA expands to other clinical opportunities, better methods to stabilize the medicines during shipping, storage, and delivery are needed.
Joshua A. Choe, Jacobus Burger, Jamie Jones, Apurva Panjla, William L. Murphy   +4 more
wiley   +1 more source

High paediatric HIV viral load rejection rate in South Africa, a retrospective review. [PDF]

South Afr J HIV Med
Murray TY, Sherman GG, Mlotshwa D, Mazanderani AFH.   +3 more
europepmc   +1 more source

CMV viral load in renal allograft recipients

, 1998
V. Mas, Teresita Alvarellos, S Albano, C Giraudo, Graciela DeBoccardo, C T Garret, A Gonzalez-Ferreyra   +6 more
openalex   +1 more source

Upconversion‐Based Remote Deep Brain Modulation for Therapeutic Dissection of Parkinson's Disease

Advanced Therapeutics, EarlyView.
An upconversion‐based wireless optogenetic strategy enables an all‐optical deep brain modulation solution for treating Parkinson's disease in rodent animals without using electronics or any tethered cables, providing experimental evidence supporting a therapeutic mechanism of STN‐DBS by disruption of anterograde signal transmission along the indirect ...
Wenchong Zhang, Xudong Lin, Kai Xie, Zixun Wang, Tianying Sun, Zhen Xu, Haibing Yue, Xi Chen, Qinghai Liao, Ming Liu, Wing Ho Yung, Jufang He, Feng Wang, Peng Shi   +13 more
wiley   +1 more source

Impact of Age and Sex on Viral Load in Hepatitis C Virus Infection. [PDF]

Viruses
Magri A, Manfredi GF, Smirne C, Pigni S, Burlone ME, Bellan M, Vercellino N, Minisini R, Pirisi M.   +8 more
europepmc   +1 more source

A study of interferon-.BETA. and interferon-.ALPHA. combination therapy for patients with chronic hepatitis C, high viral load, and genotype Ib: its efficacy for hepatic function.

, 1998
Toshihiko Mizuta, Toshiya Hara, Noriko Fukushima, Ikuko Wada, Iwata Ozaki, Kyosuke Yamamoto   +5 more
openalex   +2 more sources