Results 201 to 210 of about 3,712,649 (404)
Optimal Therapy of Hepatitis C Dynamics and Sampling Based Analysis [PDF]
arXiv, 2011 We examine two models for hepatitis C viral (HCV) dynamics, one for monotherapy with interferon (IFN) and the other for combination therapy with IFN and ribavirin. Optimal therapy for both the models is determined using the steepest gradient method, by defining an objective functional which minimizes the infected hepatocyte levels, virion population ...
arxiv
Advanced Functional Materials, EarlyView.Joule‐assisted nanotherapeutic urethral stent harnesses a smart, biodegradable magnesium stent to orchestrate spatiotemporal theragenerative therapy for urethral strictures. Magnetically induced Joule heating enables on‐demand drug release and bacterial ablation, while simultaneously guiding urothelial regeneration.
Yuhyun Na +15 more
wiley +1 more source
, 2020 We have read with interest the study published by Shoufri et al. [1] and share the idea that the current application of the WHO viral load algorithm does not allow for effective management of patients with virological failure, whereas the emergence of HIV drug resistance, so-called the fourth HIV epidemic, is obvious [2].
Breton, Guillaume +8 more
openaire +1 more source
Advanced Functional Materials, EarlyView.The Angiopep‐2 peptide density on polymeric nanoparticles significantly impacts blood–brain barrier (BBB) penetration. This study explores this nuanced relationship using various in vitro models and in vivo assays, revealing that dynamic models better predict BBB penetration.
Weisen Zhang +9 more
wiley +1 more source
Effect of zidovudine on perinatal HIV-1 transmission and maternal viral load [PDF]
, 1999 David E. Shapiro +2 more
openalex +1 more source
Advanced Functional Materials, EarlyView.Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim +8 more
wiley +1 more source
In Vivo Tropism of Hepatitis C Virus Genomic Sequences in Hematopoietic Cells: Influence of Viral Load, Viral Genotype, and Cell Phenotype [PDF]
, 1998 Hervé Lerat +6 more
openalex +1 more source
Advanced Functional Materials, EarlyView.This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley +1 more source
HIV-1 viral load and CD4 cell count in untreated children with vertically acquired asymptomatic or mild disease [PDF]
, 1998 Paediatric European Network for Treatment of AIDS
openalex +1 more source
Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks
Advanced Functional Materials, EarlyView.This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson +12 more
wiley +1 more source