Results 61 to 70 of about 3,662,996 (361)

Clinical Significance of a High SARS-CoV-2 Viral Load in the Saliva

Journal of Korean medical science, 2020
Background Patients with coronavirus disease 2019 (COVID-19) can unknowingly spread the virus to several people during the early subclinical period. Methods We evaluated the viral dynamics in various body fluid specimens, such as nasopharyngeal swab ...
J. Yoon, Jung Yoon, J. Song, Soo-Young Yoon, C. Lim, Hye-Yeong Seong, J. Noh, H. Cheong, W. Kim   +8 more
semanticscholar   +1 more source

HIV Viral Load Monitoring Among Patients Receiving Antiretroviral Therapy — Eight Sub-Saharan Africa Countries, 2013–2018

MMWR. Morbidity and mortality weekly report, 2021
One component of the Joint United Nations Programme on HIV/AIDS (UNAIDS) goal to end the HIV/AIDS epidemic by 2030, is that 95% of all persons receiving antiretroviral therapy (ART) achieve viral suppression.† Thus, testing all HIV-positive persons for ...
Shirley Lecher, P. Fonjungo, D. Ellenberger, Christiane Adje Toure, G. Alemnji, Nancy Bowen, F. Basiye, A. Beukes, S. Carmona, M. de Klerk, K. Diallo, Eric J. Dziuban, C. Kiyaga, H. Mbah, Johannes Mengistu, Tsietso Mots'oane, Christina Mwangi, J. Mwangi, M. Mwasekaga, Jonathan N'tale, M. Naluguza, Isaac Ssewanyana, W. Stevens, I. Zungu, Ravikiran Bhairavabhotla, Helen Chun, N. Gaffga, Steve Jadczak, S. Lloyd, Shon Nguyen, R. Pati, K. Sleeman, C. Zeh, Guoqing Zhang, H. Alexander   +34 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Viral Loads in Clinical Specimens and SARS Manifestations

Emerging Infectious Diseases, 2004
A retrospective viral load study was performed on clinical specimens from154 patients with laboratory-confirmed severe acute respiratory syndrome (SARS), prospectively collected during patients’ illness.
I.F.N. Hung, V.C.C. Cheng, A.K.L. Wu, B.S.F. Tang, K.H. Chan, C.M. Chu, M.M.L. Wong, W.T. Hui, L.L.M. Poon, D.M.W. Tse, K.S. Chan, P.C.Y. Woo, S.K.P. Lau, J.S.M. Peiris, K.Y. Yuen   +14 more
doaj   +1 more source

Prevalence and predictors of viral load suppression in adults living with HIV in the western region of Ghana: A cross-sectional study

AIMS Public Health, 2023
Background: Although antiretroviral therapy is beneficial and available free of cost to patients, several roadblocks still prevent patients from reaching viral suppression.
Philip Boakye, Adwoa Safowaa
doaj   +1 more source

In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age

PLoS Biology, 2020
Despite limited genomic diversity, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown a wide range of clinical manifestations in different patient populations. The mechanisms behind these host differences are still unclear.
N. Lieberman, V. Peddu, Hong Xie, L. Shrestha, Meei-Li W Huang, Megan C. Mears, M. Cajimat, D. Bente, P. Shi, F. Bovier, Pavitra Roychoudhury, K. Jerome, A. Moscona, M. Porotto, A. Greninger   +14 more
semanticscholar   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Viral Load Kinetics of SARS-CoV-2 Infection in First Two Patients in Korea

Journal of Korean medical science, 2020
As of February 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak started in China in December 2019 has been spreading in many countries in the world.
J. Y. Kim, J. Ko, Yeonjae Kim, Yae-Jean Kim, J. Kim, Yoon‐Seok Chung, Heui Man Kim, M. Han, S. Kim, B. Chin   +9 more
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

HIV viral suppression and risk of viral rebound in patients on antiretroviral therapy: a two- year retrospective cohort study in Northern Tanzania

BMC Infectious Diseases
Background The world is moving towards the third target of the Joint United Nations Programme on HIV/AIDS to ensure most people receiving antiretroviral therapy (ART) are virologically suppressed.
Monica S Kahabuka, Yimtubezinash Woldeamanuel, Peter M. Mbelele, Emmanuel A. Mpolya, Stellah G. Mpagama, Jonas P. Kessy, Tsegahun Manyazewal   +6 more
doaj   +1 more source