Results 61 to 70 of about 463,872 (305)

The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells

FEBS Letters, EarlyView.
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman, Annika Egeler, Saskia Rödl, Johannes M. Herrmann   +3 more
wiley   +1 more source

Single genome sequencing of near full-length HIV-1 RNA using a limiting dilution approach [PDF]

, 2019
Sequencing very long stretches of the HIV-1 genome can advance studies on virus evolution and in vivo recombination but remains technically challenging.
Demecheleer, Els, Hardy, Jarryt, Hebberecht, Laura, Mortier, Virginie, Schauvliege, Marlies, Staelens, Delfien, Vancoillie, Leen, Verhofstede, Chris   +7 more
core   +1 more source

Clinical relevance of nasopharyngeal SARS-CoV-2 viral load reduction in outpatients with COVID-19 [PDF]

, 2022
Jean‐Jacques Parienti, Harm‐Jan de Grooth   +1 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Viral load change and time to death among adult HIV/AIDS patients on ART after test-and-treat in Northwest Ethiopia: a retrospective multi-center follow-up study using Bayesian joint modeling

Frontiers in Public Health
IntroductionAmong patients infected with Human Immunodeficiency Virus who are on antiretroviral therapy, nearly one-fifth develop viral load rebound within 2 years of initiation of therapy. Studies on viral load change are limited in Ethiopia.
Eyob Tilahun Abeje, Eskezyiaw Agedew, Bekalu Endalew, Gedefaw Diress Alen   +3 more
doaj   +1 more source

Viral suppression rate among children tested for HIV viral load at the Amhara Public Health Institute, Bahir Dar, Ethiopia

BMC Infectious Diseases, 2019
Background Human immunodeficiency virus (HIV) infected children represent a very vulnerable population for anti-retroviral therapy (ART) drug resistance. As a global target, 90% of patients receiving ART should have HIV-RNA viral suppression. A threshold
Melashu Balew Shiferaw, Demeke Endalamaw, Mulat Hussien, Manamnot Agegne, Desalegn Amare, Fikirte Estifanos, Dinbere Temesgen   +6 more
doaj   +1 more source

Viral load could be an important determinant for fomites based transmission of viral infections

Journal of Family Medicine and Primary Care, 2021
Background and Objective: Fomites are common sources of transmission of certain infections. Infectious pathogens, such as viruses known to cause respiratory tract infections, are common examples of being transmitted by fomites.
Dhirendra P Singh, Mahesh C Sahu, Avinash Pagdhune, Ankit Viramgami, Sivaperumal Perumal, Rakesh Balachandar, Kamalesh Sarkar   +6 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Trend of viral load during the first, second, and third wave of COVID-19 in the Indian Himalayan region: an observational study of the Uttarakhand state

Frontiers in Microbiology
India had faced three waves throughout the Coronavirus disease 2019 (COVID-19) pandemic, which had already impacted economic lives and affected the healthcare setting and infrastructure.
Shailender Negi, Diksha, Deepjyoti Kalita, Neeraj Ranakoti, Ashish Negi, Diksha Kandwal, Shailesh Kumar Gupta, Yogendra Pratap Mathuria, Yogendra Pratap Mathuria   +8 more
doaj   +1 more source

Drug resistance outcomes of long-term ART with tenofovir disoproxil fumarate in the absence of virological monitoring [PDF]

, 2018
Objectives: The resistance profiles of patients receiving long-term ART in sub-Saharan Africa have been poorly described. This study obtained a sensitive assessment of the resistance patterns associated with long-term tenofovir-based ART in a ...
Appiah, Lambert T, Beloukas, Apostolos, Chadwick, David, Geretti, Anna Maria, Phillips, Richard O, Ruggiero, Alessandra, Sarfo, Fred S, Smith, Colette, Stockdale, Alexander J, Villa, Giovanni   +9 more
core   +3 more sources