Results 61 to 70 of about 257,291 (319)

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Viral suppression rate among children tested for HIV viral load at the Amhara Public Health Institute, Bahir Dar, Ethiopia

BMC Infectious Diseases, 2019
Background Human immunodeficiency virus (HIV) infected children represent a very vulnerable population for anti-retroviral therapy (ART) drug resistance. As a global target, 90% of patients receiving ART should have HIV-RNA viral suppression. A threshold
Melashu Balew Shiferaw, Demeke Endalamaw, Mulat Hussien, Manamnot Agegne, Desalegn Amare, Fikirte Estifanos, Dinbere Temesgen   +6 more
doaj   +1 more source

Modeling COVID-19 vaccine-induced immunological memory development and its links to antibody level and infectiousness [PDF]

arXiv, 2022
COVID-19 vaccines have proven to be effective against SARS-CoV-2 infection. However, the dynamics of vaccine-induced immunological memory development and neutralizing antibodies generation are not fully understood, limiting vaccine development and vaccination regimen determination. Herein, we constructed a mathematical model to characterize the vaccine-
arxiv  

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source

Trend of viral load during the first, second, and third wave of COVID-19 in the Indian Himalayan region: an observational study of the Uttarakhand state

Frontiers in Microbiology
India had faced three waves throughout the Coronavirus disease 2019 (COVID-19) pandemic, which had already impacted economic lives and affected the healthcare setting and infrastructure.
Shailender Negi, Diksha, Deepjyoti Kalita, Neeraj Ranakoti, Ashish Negi, Diksha Kandwal, Shailesh Kumar Gupta, Yogendra Pratap Mathuria, Yogendra Pratap Mathuria   +8 more
doaj   +1 more source

Association of viral kinetics, infection history, NS1 protein with plasma leakage among Indonesian dengue infected patients.

PLoS ONE, 2023
ObjectivesPlasma leakage, a hallmark of disease in Dengue virus (DENV) infection, is an important clinical manifestation and is often associated with numerous factors such as viral factors. The aim of this study is to investigate the association of virus
Leonard Nainggolan, Beti Ernawati Dewi, Arif Hakiki, Antony Joseph Pranata, Tjahjani Mirawati Sudiro, Byron Martina, Eric van Gorp   +6 more
doaj   +1 more source

Quantifying the relationship between SARS-CoV-2 viral load and infectiousness

eLife, 2021
The relationship between SARS-CoV-2 viral load and infectiousness is poorly known. Using data from a cohort of cases and high-risk contacts, we reconstructed viral load at the time of contact and inferred the probability of infection. The effect of viral
Aurélien Marc, Marion Kerioui, François Blanquart, Julie Bertrand, Oriol Mitjà, Marc Corbacho-Monné, Michael Marks, Jeremie Guedj   +7 more
doaj   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Viral load change and time to death among adult HIV/AIDS patients on ART after test-and-treat in Northwest Ethiopia: a retrospective multi-center follow-up study using Bayesian joint modeling

Frontiers in Public Health
IntroductionAmong patients infected with Human Immunodeficiency Virus who are on antiretroviral therapy, nearly one-fifth develop viral load rebound within 2 years of initiation of therapy. Studies on viral load change are limited in Ethiopia.
Eyob Tilahun Abeje, Eskezyiaw Agedew, Bekalu Endalew, Gedefaw Diress Alen   +3 more
doaj   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source