Results 61 to 70 of about 462,588 (307)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Trend of viral load during the first, second, and third wave of COVID-19 in the Indian Himalayan region: an observational study of the Uttarakhand state

Frontiers in Microbiology
India had faced three waves throughout the Coronavirus disease 2019 (COVID-19) pandemic, which had already impacted economic lives and affected the healthcare setting and infrastructure.
Shailender Negi, Diksha, Deepjyoti Kalita, Neeraj Ranakoti, Ashish Negi, Diksha Kandwal, Shailesh Kumar Gupta, Yogendra Pratap Mathuria, Yogendra Pratap Mathuria   +8 more
doaj   +1 more source

Viral suppression rate among children tested for HIV viral load at the Amhara Public Health Institute, Bahir Dar, Ethiopia

BMC Infectious Diseases, 2019
Background Human immunodeficiency virus (HIV) infected children represent a very vulnerable population for anti-retroviral therapy (ART) drug resistance. As a global target, 90% of patients receiving ART should have HIV-RNA viral suppression. A threshold
Melashu Balew Shiferaw, Demeke Endalamaw, Mulat Hussien, Manamnot Agegne, Desalegn Amare, Fikirte Estifanos, Dinbere Temesgen   +6 more
doaj   +1 more source

Is Higher Viral Load in the Upper Respiratory Tract Associated With Severe Pneumonia? Findings From the PERCH Study. [PDF]

, 2017
BACKGROUND.: The etiologic inference of identifying a pathogen in the upper respiratory tract (URT) of children with pneumonia is unclear. To determine if viral load could provide evidence of causality of pneumonia, we compared viral load in the URT of ...
Adrian, Peter V, Antonio, Martin, Awori, Juliet O, Baggett, Henry C, Baillie, Vicky L, Brooks, W Abdullah, Deloria Knoll, Maria, DeLuca, Andrea N, Driscoll, Amanda J, Ebruke, Bernard E, Feikin, Daniel R, Fu, Wei, Goswami, Doli, Hammitt, Laura L, Higdon, Melissa M, Howie, Stephen RC, Karron, Ruth A, Kotloff, Karen L, Levine, Orin S, Li, Mengying, Madhi, Shabir A, Morpeth, Susan C, Murdoch, David R, Mwaba, John, Mwansa, James, O' Brien, Katherine L, Park, Daniel E, PERCH Study Group, Prosperi, Christine, Sawatwong, Pongpun, Scott, J Anthony G, Shi, Qiyuan, Sow, Samba O, Tapia, Milagritos D, Thea, Donald M, Whistler, Toni, Zaman, Khalequ, Zeger, Scott L   +37 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Viral load change and time to death among adult HIV/AIDS patients on ART after test-and-treat in Northwest Ethiopia: a retrospective multi-center follow-up study using Bayesian joint modeling

Frontiers in Public Health
IntroductionAmong patients infected with Human Immunodeficiency Virus who are on antiretroviral therapy, nearly one-fifth develop viral load rebound within 2 years of initiation of therapy. Studies on viral load change are limited in Ethiopia.
Eyob Tilahun Abeje, Eskezyiaw Agedew, Bekalu Endalew, Gedefaw Diress Alen   +3 more
doaj   +1 more source

Costs of streamlined HIV care delivery in rural Ugandan and Kenyan clinics in the SEARCH Studys. [PDF]

, 2018
OBJECTIVES/DESIGN:As antiretroviral therapy (ART) rapidly expands in sub-Saharan Africa using new efficient care models, data on costs of these approaches are lacking. We examined costs of a streamlined HIV care delivery model within a large HIV test-and-
Aine, Ronald, Assurah, Elly, Ayieko, James, Balzer, Laura, Black, Douglas, Brown, Lillian B, Bukusi, Elizabeth A, Charlebois, Edwin D, Clark, Tamara D, Cohen, Craig R, Havlir, Diane V, Jain, Vivek, Kamya, Moses R, Kwarisiima, Dalsone, Luo, Alex, Mwai, Daniel, Mwangwa, Florence, Mwebaza, Betty, Osmand, Thomas, Owaraganise, Asiphas, Petersen, Maya L, Shade, Starley B, Thirumurthy, Harsha   +22 more
core  

Outcomes of a remote, decentralized health center-based HIV/AIDS antiretroviral program in Zambia, 2003 to 2007 [PDF]

, 2009
A cross-sectional study of patients living with HIV/ AIDS treated during 2003 to 2007 in decentralized, rural health centers in Zambia was performed to measure virological outcomes after 12 months of antiretroviral therapy and identify factors associated
Elema, R, Mills, C, Yun, O, Lokuge, K, Ssonko, C, Nyirongo, N, Mtonga, V, Zulu, H, Tu, D, Verputten, M, O'Brien, D P   +10 more
core   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Association of viral kinetics, infection history, NS1 protein with plasma leakage among Indonesian dengue infected patients.

PLoS ONE, 2023
ObjectivesPlasma leakage, a hallmark of disease in Dengue virus (DENV) infection, is an important clinical manifestation and is often associated with numerous factors such as viral factors. The aim of this study is to investigate the association of virus
Leonard Nainggolan, Beti Ernawati Dewi, Arif Hakiki, Antony Joseph Pranata, Tjahjani Mirawati Sudiro, Byron Martina, Eric van Gorp   +6 more
doaj   +1 more source