Results 71 to 80 of about 3,662,996 (361)

Quantitative SARS-CoV-2 Viral-Load Curves in Paired Saliva Samples and Nasal Swabs Inform Appropriate Respiratory Sampling Site and Analytical Test Sensitivity Required for Earliest Viral Detection

medRxiv, 2021
Early detection of SARS-CoV-2 infection is critical to reduce asymptomatic and presymptomatic transmission, curb the spread of variants, and maximize treatment efficacy.
E. Savela, A. Viloria Winnett, A. E. Romano, M. K. Porter, N. Shelby, R. Akana, J. Ji, M. M. Cooper, N. Schlenker, J. A. Reyes, A. Carter, Jacob T. Barlow, C. Tognazzini, M. Feaster, Ying-Ying Goh, R. Ismagilov   +15 more
semanticscholar   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Timing of antiviral treatment initiation is critical to reduce SARS-Cov-2 viral load

medRxiv, 2020
We modeled the viral dynamics of 13 untreated patients infected with SARS-CoV-2 to infer viral growth parameters and predict the effects of antiviral treatments.
António Gonçalves, J. Bertrand, R. Ke, E. Comets, X. D. de Lamballerie, D. Malvy, A. Pizzorno, O. Terrier, Manuel Rosa Calatrava, F. Mentré, Patrick F. Smith, A. Perelson, J. Guedj   +12 more
semanticscholar   +2 more sources

Viral Load Distribution in SARS Outbreak [PDF]

Emerging Infectious Diseases, 2005
An unprecedented community outbreak of severe acute respiratory syndrome (SARS) occurred in the Amoy Gardens, a high-rise residential complex in Hong Kong. Droplet, air, contaminated fomites, and rodent pests have been proposed to be mechanisms for transmitting SARS in a short period.
Chung-Ming Chu, Vincent C.C. Cheng, Ivan F.N. Hung, Kin-Sang Chan, Bone S.F. Tang, Thomas H.F. Tsang, Kwok-Hung Chan, Kwok-Yung Yuen   +7 more
openaire   +3 more sources

An analysis of SARS-CoV-2 viral load by patient age

medRxiv, 2020
As children are under-represented in current studies aiming to analyse transmission of SARS-coronavirus 2 (SARS-CoV-2), their contribution to transmission is unclear.
T. Jones, Barbara Mühlemann, Talitha Veith, G. Biele, M. Zuchowski, Jörg C. Hoffmann, Angela Stein, A. Edelmann, V. Corman, C. Drosten   +9 more
semanticscholar   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Assessment of Human Cytomegalovirus Viral Load in Kidney Transplant Recipients in Tehran, Iran [PDF]

, 2023
Marzieh Eslami Kojidi, Somayeh Shatizadeh Malekshahi, Mohammad Reza Jabbari   +2 more
openalex   +1 more source

Early Analysis of a potential link between viral load and the N501Y mutation in the SARS-COV-2 spike protein

medRxiv, 2021
A new variant of SARS-CoV-2 has emerged which is increasing in frequency, primarily in the South East of England (lineage B.1.1.7 ( 1 ) ; VUI-202012/01). One potential hypothesis is that infection with the new variant results in higher viral loads, which
T. Golubchik, K. Lythgoe, Matthew Hall, L. Ferretti, H. Fryer, G. Macintyre-Cockett, M. de Cesare, A. Trebes, Paolo Piazza, David Buck, John A. Todd, Christophe Fraser, D. Bonsall   +12 more
semanticscholar   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Viral load change and time to death among adult HIV/AIDS patients on ART after test-and-treat in Northwest Ethiopia: a retrospective multi-center follow-up study using Bayesian joint modeling

Frontiers in Public Health
IntroductionAmong patients infected with Human Immunodeficiency Virus who are on antiretroviral therapy, nearly one-fifth develop viral load rebound within 2 years of initiation of therapy. Studies on viral load change are limited in Ethiopia.
Eyob Tilahun Abeje, Eskezyiaw Agedew, Bekalu Endalew, Gedefaw Diress Alen   +3 more
doaj   +1 more source