Results 71 to 80 of about 463,872 (305)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Association of viral kinetics, infection history, NS1 protein with plasma leakage among Indonesian dengue infected patients.

PLoS ONE, 2023
ObjectivesPlasma leakage, a hallmark of disease in Dengue virus (DENV) infection, is an important clinical manifestation and is often associated with numerous factors such as viral factors. The aim of this study is to investigate the association of virus
Leonard Nainggolan, Beti Ernawati Dewi, Arif Hakiki, Antony Joseph Pranata, Tjahjani Mirawati Sudiro, Byron Martina, Eric van Gorp   +6 more
doaj   +1 more source

Durable Suppression of Established Transmitted Founder Replication in Infected BLT Humanized Mice by Vectored Immuno Therapy [PDF]

, 2014
Recent reports in humanized mice and monkeys have found that broadly neutralizing antibodies (bNAbs) can suppress the replication of laboratory strains of HIV and SHIV while bNAb concentration remains high.
An, Dong Sung, Balazs, Alejandro B., Baltimore, David, Deal, Cailin, Hong, Christin M., Ouyang, Yong   +5 more
core   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Changing how the third 95 is counted: suitable indicators for measuring U = U with findings from Taiwan

AIDS Research and Therapy
Introduction The World Health Organisation has implemented multiple HIV prevention policies and strived to achieve the 90-90-90 goal by 2020, achieving the 95-95-95 goal by 2030, which refers to 95% of patients living with HIV knowing their HIV status ...
Hsun-Yin Huang, Yu-Ching Huang, Hsiu-Yun Lo, Pei-Chun Chan, Chia-Chi Lee   +4 more
doaj   +1 more source

Costs of streamlined HIV care delivery in rural Ugandan and Kenyan clinics in the SEARCH Studys. [PDF]

, 2018
OBJECTIVES/DESIGN:As antiretroviral therapy (ART) rapidly expands in sub-Saharan Africa using new efficient care models, data on costs of these approaches are lacking. We examined costs of a streamlined HIV care delivery model within a large HIV test-and-
Aine, Ronald, Assurah, Elly, Ayieko, James, Balzer, Laura, Black, Douglas, Brown, Lillian B, Bukusi, Elizabeth A, Charlebois, Edwin D, Clark, Tamara D, Cohen, Craig R, Havlir, Diane V, Jain, Vivek, Kamya, Moses R, Kwarisiima, Dalsone, Luo, Alex, Mwai, Daniel, Mwangwa, Florence, Mwebaza, Betty, Osmand, Thomas, Owaraganise, Asiphas, Petersen, Maya L, Shade, Starley B, Thirumurthy, Harsha   +22 more
core  

HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy [PDF]

, 1999
The risk of disease associated with persistent virus infections such as HIV-I, hepatitis B and C, and human T-lymphotropic virus-I (HTLV-I) is strongly determined by the virus load.
Bangham, C.R.M., Bunce, M., Hall, S.E., Izumo, S., Jeffery, K.J.M., Kodama, D., Lloyd, A.L., Matsumoto, W., Nagai, M., Nowak, M.A., Ogg, G.S., Osame, M., Procter, J., Taylor, G.P., Usuku, K., Weber, J.N., Welsh, K.I.   +16 more
core   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Is Higher Viral Load in the Upper Respiratory Tract Associated With Severe Pneumonia? Findings From the PERCH Study. [PDF]

, 2017
BACKGROUND.: The etiologic inference of identifying a pathogen in the upper respiratory tract (URT) of children with pneumonia is unclear. To determine if viral load could provide evidence of causality of pneumonia, we compared viral load in the URT of ...
Adrian, Peter V, Antonio, Martin, Awori, Juliet O, Baggett, Henry C, Baillie, Vicky L, Brooks, W Abdullah, Deloria Knoll, Maria, DeLuca, Andrea N, Driscoll, Amanda J, Ebruke, Bernard E, Feikin, Daniel R, Fu, Wei, Goswami, Doli, Hammitt, Laura L, Higdon, Melissa M, Howie, Stephen RC, Karron, Ruth A, Kotloff, Karen L, Levine, Orin S, Li, Mengying, Madhi, Shabir A, Morpeth, Susan C, Murdoch, David R, Mwaba, John, Mwansa, James, O' Brien, Katherine L, Park, Daniel E, PERCH Study Group, Prosperi, Christine, Sawatwong, Pongpun, Scott, J Anthony G, Shi, Qiyuan, Sow, Samba O, Tapia, Milagritos D, Thea, Donald M, Whistler, Toni, Zaman, Khalequ, Zeger, Scott L   +37 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source