Results 321 to 330 of about 664,008 (371)

Insights into the Currently Available Drugs and Investigational Compounds Against RSV with a Focus on Their Drug-Resistance Profiles. [PDF]

Viruses
Magnapera A, Riccio A, Curcio A, Tramontozzi C, Piermatteo L, D'Anna S, Alcaro S, Alteri C, La Frazia S, Artese A, Salpini R, Svicher V.   +11 more
europepmc   +1 more source

C1q+ Macrophage–Tumor Cell Interaction Promoted Tumorigenesis via GPR17/PI3K/AKT Pathway Induced DNA Hypermethylation in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
In the TME of NPC, C1q secreted by C1q+ TAMs interacted with GPR17 to activate PI3K/AKT signaling through strengthening GPR17 coupling PI3K and increasing calcium levels in tumor cells. The activated PI3K/AKT signaling further induces DNA hypermethylation to promote the malignancy and stemness of tumor cells.
Yunzhi Liu, Cuicui Huang, Min Luo, Wenfu Lu, Baifeng Zhang, Lu Bai, Shuyue Zheng, Yanan Tan, Shanshan Li, Huali Wang, Lanqi Gong, Xinyuan Guan   +11 more
wiley   +1 more source

Identification of B cell antigens in solid cancer: initial insights and functional implications. [PDF]

Front Immunol
Yang JI, Moresco P, Fearon D, Yao M.
europepmc   +1 more source

SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy

Advanced Science, EarlyView.
During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong, Guangyu Liang, Huimin Yu, Jiaqi Li, Ruohong Wang, Xiaohong Ma, Ziqing Zhou, Yin Zhao, Fei Sun, Xufang Sun   +9 more
wiley   +1 more source

LucaPCycle: Illuminating microbial phosphorus cycling in deep-sea cold seep sediments using protein language models. [PDF]

Nat Commun
Zhang C, He Y, Wang J, Chen T, Baltar F, Hu M, Liao J, Xiao X, Li ZR, Dong X.   +9 more
europepmc   +1 more source

CD103+ T Cells Eliminate Damaged Alveolar Epithelial Type II Cells Under Oxidative Stress to Prevent Lung Tumorigenesis

Advanced Science, EarlyView.
This work unravels a novel function of CD103+ T cells in eradicating oxidative‐stressed somatic cells to prevent lung tumorigenesis and identifies specific CD103+ T cell‐decline as a key feature in the aged lung. This comprehensive study highlights the contribution of immuno‐dysregulation to the high incidence of aging‐associated lung cancers ...
Yu Xu, Haorui Luo, Jiahao Wang, Haifeng Liu, Luonan Chen, Hongbin Ji, Zimu Deng, Xiaolong Liu   +7 more
wiley   +1 more source

Autophagy machinery as exploited by viruses. [PDF]

Autophagy Rep
Münz C, Campbell GR, Esclatine A, Faure M, Labonte P, Lussignol M, Orvedahl A, Altan-Bonnet N, Bartenschlager R, Beale R, Cirone M, Espert L, Jung J, Leib D, Reggiori F, Sanyal S, Spector SA, Thiel V, Viret C, Wei Y, Wileman T, Wodrich H.   +21 more
europepmc   +1 more source

A Two‐Component Pseudo‐Icosahedral Protein Nanocompartment with Variable Shell Composition and Irregular Tiling

Advanced Science, EarlyView.
The structure and assembly principles of a two‐component encapsulin nanocompartment shell are reported. The two‐component protein compartment self‐assembles from two distinct HK97‐fold shell proteins into a pseudo‐icosahedral protein shell with variable composition and irregular tiling.
Cassandra A. Dutcher, Michael P. Andreas, Tobias W. Giessen   +2 more
wiley   +1 more source

Complete Genome Sequencing of the Divergent Guiana Dolphin Morbillivirus (GDMV), Brazil. [PDF]

Viruses
Groch KR, Miyagi SAT, Díaz-Delgado J, Santos-Neto EB, Lailson-Brito J, Brandão PE, Catão-Dias JL.   +6 more
europepmc   +1 more source

Nanoscopic acoustic vibrational dynamics of a single virus captured by ultrafast spectroscopy. [PDF]

Proc Natl Acad Sci U S A
Zhang Y, Wu R, Shahjahan M, Yang C, Pyeon D, Harel E.   +5 more
europepmc   +1 more source