Results 111 to 120 of about 295,973 (347)

An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus. [PDF]

open access: yes, 2005
A new SARS animal model was established by inoculating SARS coronavirus (SARS-CoV) into rhesus macaques (Macaca mulatta) through the nasal cavity. Pathological pulmonary changes were successively detected on days 5-60 after virus inoculation.
Chen, Liangbiao   +30 more
core  

Evaluation of Anticoagulant Proteins and Fibrinolytic System Markers in Children with Pneumonia

open access: yesJournal of Pediatric Research, 2019
Aim:Coagulation and fibrinolytic systems play an important role in the pathogenesis of complicated pneumonia. This study aims to evaluate and compare coagulation and fibrinolytic system markers and natural anticoagulant proteins with acute phase ...
Zahide Yalaki   +3 more
doaj   +1 more source

Toward the Synthesis of 3,3‐Difluoro Deaminated Sialic Acid (C3DFKDN)

open access: yesEuropean Journal of Organic Chemistry, EarlyView.
The synthesis of protected C3‐difluoro KDN (C3DFKDN), an unnatural derivative of the sialic acid member, KDN, and key building block for KDN‐based chemical probes, is reported. Its 12‐step synthetic route starts from commercially available methyl d‐mannopyranoside and key steps include a Reformatsky reaction with ethyl bromodifluoroacetate, alkylation ...
Lemeng Chao, Tom Wennekes
wiley   +1 more source

Microarray detection of human parainfluenzavirus 4 infection associated with respiratory failure in an immunocompetent adult. [PDF]

open access: yes, 2006
A pan-viral DNA microarray, the Virochip (University of California, San Francisco), was used to detect human parainfluenzavirus 4 (HPIV-4) infection in an immunocompetent adult presenting with a life-threatening acute respiratory illness.
Blackburn, Brian G   +13 more
core  

Single‐Cell Transcriptomic Analysis of the Immune Response to COVID‐19 and Tuberculosis Coinfection

open access: yesExploration, EarlyView.
Understanding the immunological basis for severe outcomes in COVID‐19/Tuberculosis coinfection is critical. Our single‐cell analysis identifies key drivers: profound lymphocyte loss through combined apoptosis and altered trafficking, excessive S100 protein‐mediated inflammation contributing to cytokine storms, and systemic immune dysfunction ...
Yi Wang   +20 more
wiley   +1 more source

Atualização em pneumonia comunitária viral

open access: yesRevista da Associação Médica Brasileira, 2013
Viral pneumonia is a prevalent cause of respiratory infection in immunocompetent adults. It has varied presentation, from mild to severe respiratory failure, requiring mechanical ventilation. However, in Brazil, there have been few studies on the clinical presentation and diagnosis of this infection.
Rocha Neto, Ozéas Galeno da   +2 more
openaire   +4 more sources

Synthetic Biology‐Based Engineering Living Therapeutics for Antimicrobial Application

open access: yesExploration, EarlyView.
This perspective highlights synthetic biology‐driven antibacterial strategies, focusing on three innovative approaches: engineered bacteriophages for precision bacterial targeting, reprogrammed microbes that detect quorum‐sensing signals or metabolites to release antimicrobials, and engineering mammalian cells that recognize pathogen‐associated ...
Shun Huang   +4 more
wiley   +1 more source

Deciphering of nutritional profile, therapeutic potential, and networking of bioactive compounds of Moringa oleifera: A comprehensive review

open access: yesFood Biomacromolecules, EarlyView.
The graphical abstract signifies the nutritional profile of various parts of the Moringa oleifera plant, including dried leaves, fresh leaves, leaf powder, seeds, and pods; along with it’s bioactive substance and protein profiling of aqueous concentrates derived from the fruit, seed, and leaf.
Rajesh Kumar   +5 more
wiley   +1 more source

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