Results 71 to 80 of about 317,906 (338)

CD27 and ICOS as Targets of PD‐1/PD‐L1 Signaling to Regulate Resident Memory CD8+ T‐Cell‐Mediated Pulmonary Protection and Pathology

open access: yesAdvanced Science, EarlyView.
Here it is revealed that the costimulatory receptors CD27 and ICOS are essential for the long‐term maintenance of PD‐1high CD8+ TRM cells following influenza infection. PD‐L1 blockade enhances the proliferation and activation of these cells through Nur77 activation downstream of the CD27/ICOS signaling axis, thereby boosting host immunity against ...
Yuanyuan Chen   +16 more
wiley   +1 more source

Investigation into the Causes and Severity of the 1918 Influenza Pandemic [PDF]

open access: yes, 2018
The 1918 Influenza outbreak is regarded as one of the worst pandemics in human history due to its widespread effects across the globe and its high death rate.
Freedenberg, Alex T.
core   +1 more source

Principles of appropriate antibiotic use for treatment of uncomplicated acute bronchitis: background. [PDF]

open access: yes, 2001
The following principles of appropriate antibiotic use for adults with acute bronchitis apply to immunocompetent adults without complicating comorbid conditions, such as chronic lung or heart disease.
Bartlett, JG   +7 more
core   +2 more sources

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

open access: yesAdvanced Science, EarlyView.
This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta   +14 more
wiley   +1 more source

Radiology of viral pneumonia

open access: yesВестник рентгенологии и радиологии, 2016
Objective: to evaluate the clinical and radiological features of viral pneumonia caused by influenza A (H1N1) in 2015–2016.Material and methods. The study involved 22 patients (13 men, 9 women, 1 patient died) with viral pneumonia caused by influenza A ...
A. A. Speranskaia   +3 more
doaj   +1 more source

On the use of clustering and the MeSH controlled vocabulary to improve MEDLINE abstract search [PDF]

open access: yes, 2005
Databases of genomic documents contain substantial amounts of structured information in addition to the texts of titles and abstracts. Unstructured information retrieval techniques fail to take advantage of the structured information available.
Blott, Stephen   +3 more
core  

Respiratory syncytial virus: Clinical and epidemiological pattern in pediatric patients admitted to a children’s hospital between 2000 and 2013 [PDF]

open access: yes, 2014
INTRODUCTION: Respiratory syncytial virus (RSV) is the major causative organism associated with acute lower respiratory tract infections in children.The objective of this study was to describe the clinical and epidemiological pattern of RSV and identify ...
Bakir, Julia   +8 more
core   +1 more source

Initial PCR Testing Negative, but Chest CT Suggesting for Viral Pneumonia Urges for Repeated Testing for COVID-19 Diagnosis [PDF]

open access: gold, 2021
Lingwei Wang   +11 more
openalex   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen   +17 more
wiley   +1 more source

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