Results 81 to 90 of about 6,360,309 (211)

How human papillomavirus replication and immune evasion strategies take advantage of the host DNA damage repair machinery [PDF]

, 2017
The DNA damage response (DDR) is a complex signalling network activated when DNA is altered by intrinsic or extrinsic agents. DDR plays important roles in genome stability and cell cycle regulation, as well as in tumour transformation.
Bordignon, Valentina, Cavallo, Ilaria, Di Domenico, Enea Gino, D’Agosto, Giovanna, Ensoli, Fabrizio, Mariani, Luciano, Pimpinelli, Fulvia, Pontone, Martina, Trento, Elisabetta   +8 more
core   +2 more sources

SKA1 promotes oncogenic properties in oral dysplasia and oral squamous cell carcinoma, and augments resistance to radiotherapy

Molecular Oncology, Volume 19, Issue 4, Page 1054-1074, April 2025.
The mitosis‐related gene SKA1 was among 629 genes consistently dysregulated in OSCC across nine public gene expression datasets. In OSCC cell lines, SKA1 promoted proliferation and migration, enhanced radioresistance, and reduced radiation‐induced senescence.
Alexander Michael Grandits, Barbara Andrea Reinoehl, Renate Wagner, Peter Kuess, Franziska Eckert, Anna Sophie Berghoff, Thorsten Fuereder, Rotraud Wieser   +7 more
wiley   +1 more source

eggNOG 4.5: a hierarchical orthology framework with improved functional annotations for eukaryotic, prokaryotic and viral sequences

Nucleic Acids Res., 2015
eggNOG is a public resource that provides Orthologous Groups (OGs) of proteins at different taxonomic levels, each with integrated and summarized functional annotations.
J. Huerta-Cepas, Damian Szklarczyk, K. Forslund, H. Cook, Davide Heller, M. Walter, T. Rattei, D. Mende, S. Sunagawa, Michael Kuhn, L. Jensen, C. V. Mering, P. Bork   +12 more
semanticscholar   +1 more source

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

Molecular Oncology, Volume 19, Issue 5, Page 1347-1370, May 2025.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar, Shima Shahbaz, Anthea C. Peters, Spencer B. Gibson, Shokrollah Elahi   +4 more
wiley   +1 more source

Nucleotide sequence and genomic organization of an ophiovirus associated with lettuce big-vein disease [PDF]

, 2002
The complete nucleotide sequence of an ophiovirus associated with lettuce big-vein disease has been elucidated. The genome consisted of four RNA molecules of approximately 7ò8, 1ò7, 1ò5 and 1ò4 kb.
Dullemans, A.M., Heuvel, J.F.J.M., van den, Verbeek, M., Wilk, F., van der   +3 more
core   +2 more sources

A Critical Phenylalanine Residue in the Respiratory Syncytial Virus Fusion Protein Cytoplasmic Tail Mediates Assembly of Internal Viral Proteins into Viral Filaments and Particles

mBio, 2012
Respiratory syncytial virus (RSV) is a single-stranded RNA virus in the Paramyxoviridae family that assembles into filamentous structures at the apical surface of polarized epithelial cells.
Fyza Y Shaikh, Reagan G. Cox, Aaron W. Lifland, Anne L. Hotard, John V. Williams, M. Moore, P. Santangelo, J. Crowe   +7 more
semanticscholar   +1 more source

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

Molecular Oncology, Volume 19, Issue 5, Page 1299-1309, May 2025.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen, Saurav Subedi, Federico La Manna, Sofia Jarrin, Irida Papapostolou, Marianna Kruithof‐de Julio, Christine Peinelt   +6 more
wiley   +1 more source

Assembly and budding of influenza virus. [PDF]

, 2004
Influenza viruses are causative agents of an acute febrile respiratory disease called influenza (commonly known as "flu") and belong to the Orthomyxoviridae family.
Barman, Subrata, Hui, Eric Ka-Wai, Nayak, Debi P   +2 more
core  

A facile quantitative assay for viral particle genesis reveals cooperativity in virion assembly and saturation of an antiviral protein [PDF]

, 2012
Conventional assays of viral particle assembly and release are time consuming and laborious. We have developed an enzymatic virus-like particle (VLP) genesis assay that rapid and quantitative and is also versatile and applicable to diverse viruses ...
Capul, Fitzpatrick, Gomis-Ruth, Gonzalez, Gottlinger, Hammonds, Hartlieb, Hatziioannou, Jasenosky, Jochmans, Jouvenet, Kaletsky, Kutluay, Martin-Serrano, Martin-Serrano, McCarthy, Morita, Neil, Neil, Paul D. Bieniasz, Perez-Caballero, Perez-Caballero, Sakuma, Sakuragi, Sam J. Wilson, Scianimanico, Shalini S. Yadav, Tang, Timmins, Van Damme, Zhou   +30 more
core   +1 more source

Viral Proteins Acquired from a Host Converge to Simplified Domain Architectures

PLoS Comput. Biol., 2012
The infection cycle of viruses creates many opportunities for the exchange of genetic material with the host. Many viruses integrate their sequences into the genome of their host for replication.
Nadav Rappoport, M. Linial
semanticscholar   +1 more source