Results 111 to 120 of about 606,321 (264)

Micro/Nanoscale Acoustic Manipulation: From Particle Control to Autonomous Microswimmers

Advanced Science, EarlyView.
This conceptual framework illustrates acoustic technology as a multifunctional platform enabling passive particle manipulation across scales and autonomous propulsion of microswimmers. ABSTRACT Acoustic manipulation and propulsion technologies have emerged as powerful platforms for micro/nanoscale control, enabled by their non‐contact operation, label ...
Jiahui Chu, Lemin Zhang, Xu Wang, Wenzong Li, Yahua Liu   +4 more
wiley   +1 more source

A retrospective cohort study of Paxlovid efficacy depending on treatment time in hospitalized COVID-19 patients

eLife
Paxlovid, a SARS-CoV-2 antiviral, not only prevents severe illness but also curtails viral shedding, lowering transmission risks from treated patients.
Zhanwei Du, Lin Wang, Yuan Bai, Yunhu Liu, Eric HY Lau, Alison P Galvani, Robert M Krug, Benjamin John Cowling, Lauren A Meyers   +8 more
doaj   +1 more source

Functional–Taxonomic Scaling Resolves Conflicting Average Genome Size Estimates Across Environmental Gradients

Advanced Science, EarlyView.
Based on genome size‐functional breadth theory, we introduce and validate a framework that adjudicates conflicting average genome size (AGS) estimates by testing which estimate yields a gap between scaled functional diversity and scaled taxonomic diversity that is consistent with the expected positive association between genome size and gene functional
Huanhuan Zhu, Xiaoye Chen, Qiushi Li, Chenyu Sun, Haihua Xia, Yingxin Huang, Cong Wang, Peilin Chen, Cheng Gao   +8 more
wiley   +1 more source

Viral and Immune Risk Factors of HIV Rebound After Interruption of Antiretroviral Therapy

The Journal of Infectious Diseases
Abstract Background Identifying risk factors for human immunodeficiency virus (HIV) rebound after treatment interruption is crucial for designing effective remission strategies. Methods Peripheral blood mononuclear cells from ...
Gianella, S, Yu, T, Wang, R, Ignacio, C, Schanz, M, Kouyos, R D, Caballero, G, Gaitan, N, Rawlings, S, Kuster, H, Metzner, K J, Gandhi, Rajesh T, Li, Jonathan Z, Günthard, H, Smith, D M, Chaillon, A   +15 more
openaire   +2 more sources

Periostin‐CCL3 Feedforward Signaling Loop Promotes Cardiac Fibrosis and Cardiomyocyte Necroptosis in Arrhythmogenic Cardiomyopathy

Advanced Science, EarlyView.
POSTN‐CCL3 signaling forms a feed‐forward circuit between cardiomyocytes and cardiac myofibroblasts in arrhythmogenic cardiomyopathy. POSTN activates JNK/RIP3‐dependent necroptotic signaling and JNK/ETS2‐induced CCL3 expression in cardiomyocytes. In turn, CCL3‐CCR5 signaling in cardiac myofibroblasts activates NF‐κB/p65 and promotes POSTN expression ...
Tiantian Wu, Ruotong Li, Xiaoyue Zhang, Dandan Chen, Jianmeng Yang, Mengmeng Li, Yuhan Yin, Ya Wang, Yuqiu Tian, Haoling Yan, Dan Cui, Jiangping Song, Gaoliang Ouyang   +12 more
wiley   +1 more source

A unifying model to explain frequent SARS-CoV-2 rebound after nirmatrelvir treatment and limited prophylactic efficacy

Nature Communications
In a pivotal trial (EPIC-HR), a 5-day course of oral ritonavir-boosted nirmatrelvir, given early during symptomatic SARS-CoV-2 infection (within three days of symptoms onset), decreased hospitalization and death by 89.1% and nasal viral load by 0.87 log ...
Shadisadat Esmaeili, Katherine Owens, Jessica Wagoner, Stephen J. Polyak, Judith M. White, Joshua T. Schiffer   +5 more
doaj   +1 more source

Factors affecting viral suppression or rebound in people living with HIV and receiving antiretroviral therapy in Ghana

Frontiers in Public Health
IntroductionRegular viral load (VL) testing for people living with HIV (PLWH) is key to attaining the Joint United Nations Program on HIV/AIDS (UNAIDS) Fast-Track 95–95-95 target to end the HIV epidemic by 2030.
Anthony T. Boateng, Anthony T. Boateng, James O. Aboagye, James O. Aboagye, Helena Lamptey, Christopher Z.-Y. Abana, Christopher Z.-Y. Abana, Araba Abaidoo-Myles, Araba Abaidoo-Myles, Darius N. K. Quansah, Darius N. K. Quansah, Seth Agyemang, Seth Agyemang, Yaw Awuku-Larbi, Gloria Ansa, Joseph Oliver-Commey, Vincent Ganu, George B. Kyei, George B. Kyei, George B. Kyei, Peter Puplampu, Evelyn Y. Bonney   +21 more
doaj   +1 more source

Re-Identifying the Rebound – What About Asymmetry? [PDF]

Rebound eff ects measure the behaviorally induced off set in the reduction of energy consumption following effi ciency improvements. Using panel estimation methods and household travel diary data collected in Germany between 1997 and 2009, this study ...
Manuel Frondel, Colin Vance
core  

Targeted Lysosomal Degradation of Extracellular and Membrane Proteins: From Receptor Hijacking to Programmable Endolysosomal Routing

Advanced Science, EarlyView.
Targeted chimeric degraders engage extracellular or membrane proteins and endocytosable cell‐surface receptors, forming ternary complexes that induce receptor‐mediated internalization. Following endocytosis, post‐endocytic sorting—not internalization alone—determines target fate.
Ke Liu, Xiyan Wang, Xiaozhen Liu, Chaoqi He, Da Qian, Xuli Meng, Liquan Zhu   +6 more
wiley   +1 more source

RETHINKING ECONOMY-WIDE REBOUND MEASURES: AN UNBIASED PROPOSAL [PDF]

In spite of having been first introduced in the last half of the ninetieth century, the debate about the possible rebound effects from energy efficiency improvements is still an open question in the economic literature.
Ana-Isabel Guerra, Ferran Sancho
core