Results 61 to 70 of about 853,787 (154)

Development of plant‐derived biomimetic nanoparticles as a novel targeted drug delivery platform

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Plant‐derived biomimetic nanoparticles (PD‐BNPs) represent a sustainable and biocompatible nanoplatform for targeted drug delivery. This review highlights their therapeutic potential, engineering strategies, and translational challenges toward precision nanomedicine applications. Abstract Plant‐derived biomimetic nanoparticles (PD‐BNPs) have emerged as
Jihad Hasan, Asnaf Nihan Shuvo, Md. Rezaul Karim Sheikh, A. Nayeem Faruqui   +3 more
wiley   +1 more source

Phase I Randomised Clinical Trial of an HIV-1(CN54), Clade C, Trimeric Envelope Vaccine Candidate Delivered Vaginally. [PDF]

, 2011
We conducted a phase 1 double-blind randomised controlled trial (RCT) of a HIV-1 envelope protein (CN54 gp140) candidate vaccine delivered vaginally to assess immunogenicity and safety.
Fraser Carol A., Wiggins, RC, Cai Chun, David J Lewis, David J. Lewis, Maria Woodrow, Martin P. Cranage, Manoussaka, Maria, Wiggins Rebecca C., Giemza, Rafaela, Giemza Rafaela, Fraser, CA, Alethea Cope, Cai, Chun, Lacey, Charles J, Cranage Martin P., Cai, C, Cope Alethea, Abdel N Mahmoud, Cope, A, Tom Cole, Robin J Shattock, Jeffs, Simon A, Shattock, RJ, Rebecca C. Wiggins, Maria Manoussaka, Charles J Lacey, Charles J. Lacey, Manoussaka Maria, Cranage, Martin P, Cole Tom, Martin P Cranage, Lewis David J., Shattock, Robin J, Lacey, CJ, Jeffs Simon A., Woodrow, M, Manoussaka, M, Lewis, David J, Rafaela Giemza, Chun Cai, Mahmoud Abdel N., Robin J. Shattock, Wiggins, Rebecca C, Cole, Tom, Simon A. Jeffs, Shattock Robin J., Fraser, Carol A, Mahmoud, AN, Simon A Jeffs, Lewis, DJ, Giemza, R, Carol A Fraser, Woodrow, Maria, Jeffs, SA, Carol A. Fraser, Woodrow Maria, Cole, T, Cope, Alethea, Abdel N. Mahmoud, Mahmoud, Abdel N, Rebecca C Wiggins, Cranage, MP, Lacey Charles J.   +63 more
core   +2 more sources

A Modular Mechanistic In Silico Model for In Vitro Transcription Process Yield and Product Quality Prediction

Biotechnology and Bioengineering, Volume 123, Issue 7, Page 1836-1870, July 2026.
ABSTRACT In vitro transcription (IVT) plays a critical role in the manufacture of mRNA vaccines and therapeutics. Optimizing mRNA yield and ensuring product quality, such as capping efficiency and integrity, are essential but mechanistically complex. This study presents a modular mechanistic model of the IVT process to advance scientific understanding ...
Keqi Wang, Keilung Choy, Eli Reiser, Jinxiang Pei, Hua Zheng, Aparajita Dasgupta, Fuqiang Cheng, Guogang Dong, Bhanu Chandra Mulukutla, Joshua Mannheimer, Carolyn Huang, Hooman Farsani, Wei Xie   +12 more
wiley   +1 more source

A 5-year follow-up of antibody response in children vaccinated with single dose of live attenuated SA14-14-2 Japanese encephalitis vaccine: immunogenicity and anamnestic responses

, 2008
Out of 98 subjects who had participated in the 2000 JE vaccination campaign, 69 people were enrolled in the tests of 2004 and 2005 for the evaluation of long term immune response of a single dose of live attenuated SA14-14-2 JE vaccine.
오희철
core   +1 more source

Mixed‐mode membrane chromatography: mechanistic‐modeling‐based optimization and scale‐up of antibody charge variant separation using a novel membrane adsorber

Journal of Chemical Technology &Biotechnology, Volume 101, Issue 7, Page 1407-1419, July 2026.
Abstract BACKGROUND Efficient manufacturing of complex biopharmaceuticals increasingly relies on innovative downstream processing strategies. Membrane chromatography offers a promising alternative to resin‐based systems by enabling high‐throughput separations at elevated flow rates. Typically used in flow‐through mode, its industrial applications range
Jan Hedrich, Rita Steigmiller, Viktor Simaev, Romas Skudas, Michael Schulte, Mathias Hafner, Christian Frech   +6 more
wiley   +1 more source

Real‐Time Monitoring of In Vitro Transcription for Production of mRNA Using Raman Spectroscopy

Biotechnology and Bioengineering, Volume 123, Issue 6, Page 1594-1604, June 2026.
Schematic depicting the workflow for model building and validation using Raman spectroscopy for real‐time monitoring of IVT. ABSTRACT The success of COVID‐19 mRNA vaccines showcased the transformative potential of this adaptable, plug‐and‐play, and rapid response platform.
Julia Puppin Chaves Fulber, Xingge Xu, Hadi El Radi, Kevin Grollier, Amine A. Kamen   +4 more
wiley   +1 more source

Production and Purification of Mesenchymal Stem Cell‐Derived Extracellular Vesicles Using Preferential Exclusion Chromatography

ELECTROPHORESIS, Volume 47, Issue 6, Page 533-542, June 2026.
A scalable purification strategy using hydroxyl (OH) monolithic chromatography enables efficient isolation and direct concentration of MSC‐EVs from adherent and microcarrier‐based upstreams. This approach supports process scale‐up while ensuring high purity suitable for therapeutic EV manufacturing.
Katja Vrabec, Andrej Raspor, Darja Božič, Nastja Bizjak Ternik, Ana Železnik, Valentina Novak, Ivana Petrović Koshmak, Maja Leskovec, Aleš Štrancar   +8 more
wiley   +1 more source

Single dose of SA 14-14-2 vaccine provides long-term protection against Japanese encephalitis: A case-control study in Nepalese children 5 years after immunization

, 2007
In July 1999, a single dose of live-attenuated SA 14-14-2 Japanese encephalitis (JE) vaccine was administered to children living in the Bardiya, Banke and Kailali districts of Nepal.
오희철, 남정모
core   +1 more source

Reliability of medical students' vaccination histories for immunisable diseases [PDF]

, 2008
Background Medical students come into contact with infectious diseases early on their career. Immunity against vaccine-preventable diseases is therefore vital for both medical students and the patients with whom they come into contact.
René Gottschalk, Allwinn Regina, Allwinn, Regina, Gottschalk, René, Sabine Wicker, Regina Allwinn, Rabenau, Holger, Holger F Rabenau, Gottschalk René, Rabenau Holger F, Wicker, Sabine, Wicker Sabine   +11 more
core   +2 more sources

Malaria immunology and vaccine development

, 2008
This thesis describes work undertaken by the author at the University of Oxford. Itbegins by providing an introduction to malaria infection and pathophysiology, anda review of the latest attempts to produce an effective malaria vaccine.
Thompson, Fiona Mary
core   +1 more source