Results 261 to 270 of about 349,023 (332)

Host Cell Protein Clinical Safety Risk Assessment—An Updated Industry Review

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Host cell proteins (HCP) are process‐related impurities that can co‐purify with therapeutic proteins. Some HCP impurities potentially can have an impact on patient safety (immunogenicity or toxicity), efficacy, and/or product quality. It is important to reduce the levels of HCP impurities with a well‐controlled manufacturing process and to ...
Lisette Coye, Marisa A. Jones, Georgeen Gaza‐Bulseco, Carmelata Chitikila, Severine Clavier, Delphine Fougeron, Christine Grimaldi, Karen Hurkmans, Richard Hutchinson, Brenda Kellogg, Xinrong Liu, Nisha Palackal, Mahima Tank, Pascal Valax, Thomas Waerner, Fengqiang Wang, Ying Zhang, Yiwei Zhao, Sapphire Sloan, Christina Zuch de Zafra   +19 more
wiley   +1 more source

Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis

BMEMat, EarlyView.
This review introduces the mechanism that exosomes participate in the pathogenesis of periodontitis and their potential as biomarkers for early diagnosis and summarizes the application of cell‐ or plant‐derived exosomes or engineered exosomes in periodontitis or periodontal regeneration while proposing the perspective of translational application of ...
Yu Wang, Yuchen Li, Yunfan Zhang, Chenshuang Li, Yifan Lin, Si Chen, Bing Han   +6 more
wiley   +1 more source

Vaccines for Viral and Parasitic Diseases Produced with Baculovirus Vectors

, 2006
Monique M. van Oers
openalex   +1 more source

Harnessing nanomaterials to precisely regulate the immunosuppressive tumor microenvironment for enhanced immunotherapy

BMEMat, EarlyView.
The immunosuppressive tumor microenvironment, characterized by hypoxia, redox imbalance, elevated interstitial fluid pressure, and acidity, was comprehensively elucidated. This review discussed the etiology and consequences of the characteristics of the immunosuppressive tumor microenvironment, and analyzed the recent advancements in nanomaterials for ...
Wen Zhang, Xueyin Hu, Wei Cheng, Lumeng Zhang, Yuanfang Chen, Qinrui Fu, Luntao Liu, Saijun Fan   +7 more
wiley   +1 more source

Viral evolution in macaques coinfected with CCR5- and CXCR4-tropic SHIVs in the presence or absence of vaccine-elicited anti-CCR5 SHIV neutralizing antibodies

, 2006
Brian Burke, Nina Derby, Zane Kraft, Cheryl J. Saunders, Chuanbin Dai, Nicholas Llewellyn, Irina Zharkikh, Lucia Vojtech, Tuofu Zhu, Indresh K. Srivastava, Susan W. Barnett, Leonidas Stamatatos   +11 more
openalex   +1 more source

Continuous purification of a parvovirus using two aqueous two‐phase extraction steps

Biotechnology Progress, EarlyView.
Abstract Aqueous two‐phase systems (ATPS) are a liquid–liquid extraction method that offers low‐cost, continuous‐adaptable virus purification. A two‐step ATPS using polyethylene glycol (PEG) and sodium citrate that recovered 66% of infectious porcine parvovirus with 2.0 logs of protein removal and 1.0 logs of DNA removal in batch has now been run ...
Natalie M. Nold, Sheridan Waldack, Grace James, Trisha Colling, Lynn Manchester, Taravat Sarvari, Amanda Bekkala, Seth A. Kriz, Madison Baldwin, Emily Agustin‐Mazariegos, Michael J. Betenbaugh, Caryn L. Heldt   +11 more
wiley   +1 more source

Coping with Viral Diversity in HIV Vaccine Design

, 2007
David C. Nickle, Morgane Rolland, Mark A. Jensen, Sergei L. Kosakovsky Pond, Wenjie Deng, Mark L. Seligman, David Heckerman, James I. Mullins, Nebojša Jojić   +8 more
openalex   +2 more sources

Minimizing batch‐to‐batch variability of a live virus vaccine by process analytical technologies

Biotechnology Progress, EarlyView.
Abstract For bioprocesses producing live virus, such as enterovirus Coxsackievirus A21, viral titer (infectivity basis) decay rates can exceed 30% within a day. Consequently, harvest timing is paramount. To optimize titer at harvest, a continuous viral product titer model was generated to elucidate kinetics.
Katherine Forrester, Thomas R. Blanda, Marena Trauger, Rachel Thompson, Neil Templeton   +4 more
wiley   +1 more source

Expert Perspective: Hematologic Malignancies and Vasculitis

Arthritis &Rheumatology, EarlyView.
Michelle L. Robinette, Hetty E. Carraway
wiley   +1 more source

Transcriptomic functional characterization of recombinant adeno‐associated virus producing cell line adapted to suspension‐growth

Biotechnology Progress, EarlyView.
Abstract Recombinant adeno‐associated virus (rAAV) is a widely used delivery vehicle in gene therapy. A scalable production technology is essential for its wide clinical applications. We have taken a synthetic biology approach to generate HEK293‐based cell lines which harbor integrated genetic elements encoding essential AAV and adenoviral helper ...
Han‐Jung Kuo, Prahalad Srinivasan, Yu‐Chieh Lin, Min Lu, Carissa Rungkittikhun, Qi Zhang, Wei‐Shou Hu   +6 more
wiley   +1 more source