Results 161 to 170 of about 1,876,696 (266)

Mechanistic model for HEK293 viral vector processes and its application in a digital shadow framework. [PDF]

Bioprocess Biosyst Eng
Kuchemüller KB, Austerjost J, Machleid R, Roßkamp A, Niemann J, McCready C.   +5 more
europepmc   +1 more source

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Viral hepatitis surveillance and case management : guidance for state, territorial, and local health departments [PDF]

Since the 2005 edition of the Guidelines for Viral Hepatitis Surveillance and Case Management, the epidemiology of viral hepatitis in the United States has changed substantially.

core  

Rhino-Orbital Mucormycosis Following COVID-19 Viral Vector Vaccination in an Immunocompetent Patient. [PDF]

J Fungi (Basel)
Strianese D, Troisi M, Iuliano A, Cohen D, Matarazzo F, Laezza MP, Pinchera B, Passaro ML, Tramontano D, Lanni V, D'Aponte A, Gentile I, Costagliola C.   +12 more
europepmc   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

Sex Differences in Response to Viral Vector Vaccines-Implications for Future Vaccine Design. [PDF]

Immunol Rev
Grewe I, Zoran T, Addo MM.
europepmc   +1 more source

Systematic Position Mapping of Split CRISPR‐Cas12a Activators Enables Highly Sensitive miRNA Detection and Cancer Cell Stratification

Advanced Science, EarlyView.
ABSTRACT Amplification‐free Cas12a diagnostics with split crRNA enable rapid and programmable target recognition, yet insufficient understanding of DNA activator architecture prevents predictable control over trans‐cleavage activity and sensitivity. Here we systematically map over 200 split DNA activator configurations by introducing nicks at every ...
Xiaoyan Tang, Zhe Li, Yuning Lu, Miao Ma, Zijian Mo, Jiajun Ke, Xinyu Luan, Tiangang Luan, Junqiu Zhai   +8 more
wiley   +1 more source

Rapid and robust immune response boosting with potent, next-generation adjuvant in viral vector-primed primates. [PDF]

J Virol
King HAD, Subra C, Tourtellott E, Swafford I, Basu S, Rossman M, Phillips L, Obarorakpor N, Ding S, Ferrari MG, Beck Z, Lewitus E, Bai H, Dong M, Slike BM, Kim D, Dussupt V, Mendez-Rivera L, Eisel N, Zhang L, Williams LD, Tomaras GD, Finzi A, Matyas GR, Krebs SJ, Rolland M, Rao M, Paquin-Proulx D, Bolton DL.   +28 more
europepmc   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

Rethinking viral vector quantification: a microfluidic approach to standardised functional titre assays. [PDF]

Front Bioeng Biotechnol
Farcas DA, Moore-Kelly C, Stevenson P, Raposo RAS, Marques MPC, Szita N.   +5 more
europepmc   +1 more source