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Gene Therapy with Viral Vectors
Annual Review of Pharmacology and Toxicology, 2003A key factor in the success of gene therapy is the development of gene delivery systems that are capable of efficient gene transfer in a broad variety of tissues, without causing any pathogenic effect. Currently, viral vectors based on many different viruses have been developed, and their performance and pathogenicity has been evaluated in animal ...
Neeltje A, Kootstra, Inder M, Verma
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Viral Vectors for Gene Transfer
Current Protocols in Mouse Biology, 2018AbstractViral vectors are a promising tool for effective delivery of genetic material into cells. They take advantage of the natural ability of a virus to deliver a genetic payload into cells while being genetically modified such that their ability to replicate is crippled or removed. Here, an updated overview of routinely used viral vectors, including
Yong Hong, Chen +2 more
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Acta Ophthalmologica, 2014
AbstractThere are a number of ongoing clinical trials that utilise viral vectors to deliver potentially therapeutic genetic material to retinal cells. This talk will look at the major consideration of turning a wildtype virus into a clinical trial vector. These include the packaging capacity, tropism (preference for targeting specific cells/tissue) and
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AbstractThere are a number of ongoing clinical trials that utilise viral vectors to deliver potentially therapeutic genetic material to retinal cells. This talk will look at the major consideration of turning a wildtype virus into a clinical trial vector. These include the packaging capacity, tropism (preference for targeting specific cells/tissue) and
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Annual Review of Microbiology, 1995
The use of DNA as a drug is both appealing and simple in concept. Indeed in many instances the feasibility of such an approach has been established using model systems. In practical terms, however, the delivery of DNA to human tissues presents a wide variety of problems that differ with each potential therapeutic application. In this review, the design,
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The use of DNA as a drug is both appealing and simple in concept. Indeed in many instances the feasibility of such an approach has been established using model systems. In practical terms, however, the delivery of DNA to human tissues presents a wide variety of problems that differ with each potential therapeutic application. In this review, the design,
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Viral Vectors for Cancer Immunotherapy
Frontiers in Bioscience, 2006Over the last decade, immunotherapy approaches for the treatment of cancer have been investigated with renewed vigour, perhaps catalyzed by the clinical successes seen with monoclonal antibody and cytokine based therapies. The identification of tumor-associated antigens (TAAs) in multiple cancer types has enabled the development of targeted ...
Richard, Harrop, Miles W, Carroll
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Viral Vector Production: Adenovirus
2016Adenoviral vectors have proven to be valuable resources in the development of novel therapies aimed at targeting pathological conditions of the central nervous system, including Alzheimer's disease and neoplastic brain lesions. Not only can some genetically engineered adenoviral vectors achieve remarkably efficient and specific gene delivery to target ...
Julius W, Kim +5 more
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Viral vectors as vaccine carriers
Current Opinion in Virology, 2016This chapter reviews the performance of viral vectors based on adenoviruses or adeno-associated virus as vaccine carriers for infectious diseases. Replication-defective adenovirus vectors based on multiple human or non-human serotypes have consistently induced potent transgene product-specific B and T cell responses and are increasingly being explored ...
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Progress of cationic gene delivery reagents for non-viral vector
Applied Microbiology and Biotechnology, 2021Kai Ma +3 more
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Geminiviruses: plant viral vectors
Current Opinion in Genetics & Development, 1993Geminiviruses are being used as convenient autonomously replicating vectors for foreign gene amplification in plants. Using tissue culture techniques, they have been adapted for the analysis of the regulation of gene expression in a wide range of hosts, including both mono- and dicotyledonous species.
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