Results 211 to 220 of about 497,332 (389)

Intracellular Penetration of Atazanavir, Ritonavir and Dolutegravir With Concomitant Rifampicin: A Dose Escalation Study

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Ritonavir‐boosted atazanavir is a victim of drug–drug interaction with rifampicin, a key component of antitubercular treatment. In a recent dose escalation clinical trial, we showed that increasing atazanavir/ritonavir to 300/100 mg b.i.d. compensates for reduced drug exposure in plasma due to rifampicin, but the intracellular effects remained ...
Amedeo De Nicolò   +16 more
wiley   +1 more source

Model‐Based Prediction of Clinically Relevant Thrombocytopenia after Allogeneic Hematopoietic Stem Cell Transplantation

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Platelet reconstitution after allogeneic hematopoietic cell transplantation (allo‐HCT) is heterogeneous and influenced by various patient‐ and transplantation‐related factors, associated with poor prognoses for poor graft function (PGF) and isolated thrombocytopenia.
Katharina M. Götz   +23 more
wiley   +1 more source

EGFR‐HER2 Transactivation Viewed in Space and Time Through the Versatile Spectacles of Imaging Cytometry—Implications for Targeted Therapy

open access: yesCytometry Part A, EarlyView.
ABSTRACT Ligand‐induced formation of signaling platforms composed of homo‐ and/or heterodimers of receptor tyrosine kinases is considered essential for their activation and consequential contribution to the progression of many cancers. Epidermal Growth Factor Receptor (EGFR) acts as a signal receiver upon EGF binding and produces mitogenic input for ...
László Ujlaky‐Nagy   +2 more
wiley   +1 more source

Enhancing Bacterial Phenotype Classification Through the Integration of Autogating and Automated Machine Learning in Flow Cytometric Analysis

open access: yesCytometry Part A, EarlyView.
ABSTRACT Although flow cytometry produces reliable results, the data processing from gating to fingerprinting is prone to subjective bias. Here, we integrated autogating with Automated Machine Learning in flow cytometry to enhance the classification of bacterial phenotypes.
In Jae Jeong   +3 more
wiley   +1 more source

Single‐Calibration Cell Size Measurement With Flow Cytometry

open access: yesCytometry Part A, EarlyView.
ABSTRACT Measuring the size of individual cells in high‐throughput experiments is often important in biomedical research and applications. Nevertheless, popular tools for high‐throughput single‐cell biology, such as flow cytometers, only offer proxies of a cell's size, typically reported in arbitrary scales and often subject to changes in the ...
Philip Davies   +2 more
wiley   +1 more source

OMIP‐111: Immune‐Profiling of T Helper 1 (Th1), Th2, and Th17 Signatures in Murine Splenocytes by Targeting Intracellular Cytokines

open access: yesCytometry Part A, EarlyView.
ABSTRACT Functional cytokines shape both innate and adaptive immune responses in the host after infection or immunization. Deep immunophenotyping of the key functional cytokine signatures associated with T cells in murine lymphoid tissue, especially in the spleen, is challenging.
Soumik Barman   +8 more
wiley   +1 more source

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