Results 241 to 250 of about 517,992 (346)

HiFi based metagenomic assembly strategy provides accuracy near isolated genome resolution in MAG assembly

open access: yesiMetaOmics, EarlyView.
Recovering high‐contiguity, circular bacterial genomes from complex microbiomes (e.g., gut) is challenged by limitations of short‐read and error‐prone long‐read sequencing. This study comprehensively compares PacBio High‐Fidelity (HiFi) sequencing‐based metagenome‐assembled genomes (MAGs) against Illumina MAGs, Oxford Nanopore Technologies (ONT) MAGs ...
Feilong Deng   +7 more
wiley   +1 more source

A reciprocal interaction between L‐lysine and Holdemanella biformis modulates intestinal barrier function and anxiety in irritable bowel syndrome

open access: yesiMetaOmics, EarlyView.
This study uncovers a complex interaction between l‐lysine and Holdemanella biformis (H. biformis) in irritable bowel syndrome (IBS). l‐lysine enhances intestinal barrier function and alleviates anxiety‐like behaviours by modulating tryptophan metabolism. In contrast, H. biformis improves gut barrier integrity but exacerbates anxiety‐like behaviours. H.
Chun‐Hui Jiang   +9 more
wiley   +1 more source

Distinctive metabolic disturbances associated with redox homeostasis, nervous and hormonal functions during gut microbial enrichment upon polystyrene microplastic exposure

open access: yesiMetaOmics, EarlyView.
Microplastic‐induced gut microbial enrichment was dominated by bacteria within Eubacteriales, correlated with the virome, and accompanied by colitis. The polyamine synthetic pathway was activated to maintain glutathionylspermidine homeostasis, concurrent with decreases in pathways involved in the production of energy and reactive oxygen species under ...
Guozhu Ye   +6 more
wiley   +1 more source

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