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Mathematical Modeling of Oncolytic Virotherapy
2019Mathematical modeling in biology has a long history as it allows the analysis and simulation of complex dynamic biological systems at little cost. A mathematical model trained on experimental or clinical data can be used to generate and evaluate hypotheses, to ask "what if" questions, and to perform in silico experiments to guide future experimentation
Johannes P W Heidbuechel +4 more
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Oncolytic virotherapy for multiple myeloma
Expert Opinion on Biological Therapy, 2008Current therapies for multiple myeloma (MM) are not curative, thus novel targeted therapeutics are being developed. One such targeted therapy is oncolytic virotherapy, wherein viruses specifically infect and kill the malignant plasma cells, leaving normal cells intact.This review provides an overview of the mechanisms and results of the oncolytic ...
Amaalia E Stief, J. Andrea McCart
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Oncolytic Virotherapy of Cancer
2010It has been almost two decades since the first genetically engineered oncolytic virus was reported in 1991. Since then, many novel strategies have been developed to further improve oncolytic virus tumor selectivity and antitumoral potency, which are the two most important factors that would eventually determine the clinical safety and efficacy of any ...
Aladar A. Szalay +3 more
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Gene Therapy and Virotherapy of Gliomas
2018Despite many recent advances in the management of gliomas, such as aggressive surgical resection, chemoradiotherapy, antiangiogenic therapy, and molecular targeted therapy, the survival of patients with high-grade neoplasms remains dismal. Gene therapy and oncolytic virotherapy have emerged as highly promising strategies for treatment of malignant ...
Maciej S. Lesniak +5 more
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Optimizing oncolytic virotherapy in cancer treatment
Nature reviews. Drug discovery, 2019K. Harrington +4 more
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Viral Oncolysis or Virotherapy
2014The concept of using a virus to “kill” a tumor dates back to the beginning of the 1990’s when it was noticed that occasionally a tumor would shrink following a viral infection. This concept was tested from the 1950s until the 1970s in animal models, and in a few human trials.
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Fractional time-delay mathematical modeling of Oncolytic Virotherapy
, 2021Pushpendra Kumar +3 more
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Virotherapy of peritoneal carcinomatosis
Zeitschrift für Gastroenterologie, 2013Michael Bitzer +14 more
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InFo Onkologie, 2018