Results 201 to 210 of about 8,210 (263)

Opening closed inward rectifier potassium channel doors

British Journal of Pharmacology, EarlyView.
Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger, Fabian Kaiser, Marcel A. G. van der Heyden, Saïd Bendahhou   +3 more
wiley   +1 more source

Reduced prediction updating shapes serial dependence in autistic traits. [PDF]

BMC Biol
Pomè A, Wiesing M, Zimmermann E.
europepmc   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Bridging the gap between haptic devices and cobots with highly geared magnetorheological actuators. [PDF]

Sci Rep
Plante JS, St-Jean A, Lucking Bigué JP.
europepmc   +1 more source

Higher sensitivity to ouabain‐induced toxicity in human induced pluripotent stem cell‐derived cardiomyocytes than human adult heart tissue despite similar Na+/K+‐ATPase pump current amplitudes

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CM) have gained interest as a pharmacological model but their immaturity leads to uncertainty regarding translation. We studied the key player in maintaining ionic homeostasis, the Na+/K+‐ATPase (NKA), in hiPSC‐CM.
Djemail Ismaili, Paavo Virtanen, Junsoo Im, Paul Brunnbauer, Umber Saleem, Muhammed Ikbal Sönmez, Carl Schulz, Margaret Nandudu, Joris Winters, Cristina E. Molina, Johannes Petersen, Monika Stoll, Ulrich Schotten, Arne Hansen, Thomas Eschenhagen, Jussi T. Koivumäki, Torsten Christ   +16 more
wiley   +1 more source

Design and Control of a Wheeled Bipedal Robot Based on Hybrid Linear Quadratic Regulator and Proportional-Derivative Control. [PDF]

Sensors (Basel)
Xu Y, Wang Z, Lu C.
europepmc   +1 more source

Dissociating role of Bassoon in glutamatergic and dopaminergic neurons in alcohol‐related behaviour and affective state in mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Alcohol abuse and affective disorders are severe comorbid psychiatric diseases characterized by impaired brain synaptic transmission. The role of presynaptic scaffolding proteins coordinating presynaptic plasticity and neurotransmitter release, such as Bassoon (Bsn), in the pathogenesis of these disorders remains elusive.
Liubov S. Kalinichenko, Mona Krenbauer, Janosh Isert, Marlon Kamlah, Thorben Tanzer, Hannes Rödel, Tobias Müller, Anil Annamneedi, Enes Yağız Akdaş, Volker Eulenburg, Bernd Lenz, Eckart D. Gundelfinger, Johannes Kornhuber, Anna Fejtova, Christian P. Müller   +14 more
wiley   +1 more source

A decade of greener care: Environmental, economic, and operational impact of the virtual stone clinic in the United Kingdom. [PDF]

Cent European J Urol
Khalifa S, Makia A, Saleem H, Hughes T, Nada M, Tear L, Davis T, Somani BK.   +7 more
europepmc   +1 more source

MaX4Zero: Masked Extended Attention for Zero‐Shot Virtual Try‐On In The Wild

Computer Graphics Forum, EarlyView.
Max4Zero is a zero‐shot, training‐free virtual try‐on method that leverages diffusion priors and extended attention for accurate garment transfer. By warping reference garments and mitigating texture sticking, it achieves superior fidelity, garment preservation and identity consistency over state‐of‐the‐art methods without additional training ...
Nadav Orzech, Yotam Nitzan, Ulysse Mizrahi, Dov Danon, Amit H. Bermano   +4 more
wiley   +1 more source

Energy-Efficient Actuation for Wearable Exoskeletons: A Virtual Prototype. [PDF]

Appl Bionics Biomech
Ghaffar A, Rehman A, Riaz MT, Mahmud MMSA.   +3 more
europepmc   +1 more source