Results 201 to 210 of about 11,389 (285)

Cancer pain: current practice and emerging targets

open access: yesBritish Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye   +5 more
wiley   +1 more source

A novel selective stabilizer of the ryanodine receptor 2 prevents stress‐induced ventricular arrhythmias without impairing cardiac function

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Aberrant activation of type 2 ryanodine receptors (RyR2) causes lethal arrhythmias, such as catecholaminergic polymorphic ventricular tachycardia (CPVT). Developing drugs that suppress RyR2 hyperactivation may be key to novel arrhythmia treatments.
Nagomi Kurebayashi   +29 more
wiley   +1 more source

Personality at the Centre: How Network Brokerage and Traits Shape Voice Behaviour in Online Communities

open access: yesCreativity and Innovation Management, EarlyView.
ABSTRACT Changing the status quo and promoting innovation requires individuals to speak up and engage in voice behaviour. Yet, the interactions that foster or inhibit voice remain insufficiently understood, particularly with regard to personal agency, how an individual's personality interacts with their network position to influence voice.
Léonie Sophia Lange   +2 more
wiley   +1 more source

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

open access: yesCancer Science, EarlyView.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo   +6 more
wiley   +1 more source

MaX4Zero: Masked Extended Attention for Zero‐Shot Virtual Try‐On In The Wild

open access: yesComputer Graphics Forum, EarlyView.
Max4Zero is a zero‐shot, training‐free virtual try‐on method that leverages diffusion priors and extended attention for accurate garment transfer. By warping reference garments and mitigating texture sticking, it achieves superior fidelity, garment preservation and identity consistency over state‐of‐the‐art methods without additional training ...
Nadav Orzech   +4 more
wiley   +1 more source

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