Results 211 to 220 of about 8,561 (290)

The Effect of Traffic Congestion on Labour Investment Efficiency

open access: yesEuropean Financial Management, EarlyView.
ABSTRACT The study examines the effects of headquarters‐city traffic congestion on labour investment efficiency. The results indicate that firms headquartered in congested cities may engage in inefficient labour investment decisions. Further analysis indicates that the inefficiency is associated with both overinvestment and underinvestment in labour ...
Rajib Chowdhury
wiley   +1 more source

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

open access: yesThe FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti   +11 more
wiley   +1 more source

The pharmacology of gepants in migraine: A scoping review on mechanisms, clinical applications, and combination strategies

open access: yesHeadache: The Journal of Head and Face Pain, EarlyView.
Abstract Background Calcitonin gene‐related peptide (CGRP) is a key mediator in migraine pathophysiology, and the development of gepants, novel CGRP receptor antagonists, has expanded therapeutic options for both acute and preventive treatment. This scoping review aims to synthesize current evidence on the pharmacology, clinical applications, safety ...
Luigi Francesco Iannone   +5 more
wiley   +1 more source

We Need to Talk About Court Custody

open access: yesThe Howard Journal of Crime and Justice, EarlyView.
ABSTRACT Court custody is an overlooked but significant site of incarceration that holds tens of thousands of individuals each year in England and Wales. Providing one of the first scholarly investigations of court custody, we find that insurmountable bureaucratic barriers make it impossible to conduct interview‐based empirical research within court ...
Tom Kemp, Philippa Tomczak
wiley   +1 more source

How Does Progressivity Affect the Tax Cut Multiplier?

open access: yesInternational Economic Review, EarlyView.
ABSTRACT How does the targeting of personal income tax cuts affect the output multiplier? This paper provides quantitative evidence using a heterogeneous‐agent New‐Keynesian model calibrated to match US distributions of income, wealth, marginal tax rates, and marginal propensities to consume.
Christian Gillitzer
wiley   +1 more source

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