Results 161 to 170 of about 880,171 (288)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Spectral Decomposition of Chemical Semantics for Activity Cliffs‐Aware Molecular Property Prediction

Advanced Science, EarlyView.
PrismNet mimics chemical intuition by functioning as a computational prism, refracting molecular graphs into complementary semantic views and spectral frequencies. This dual‐decomposition strategy effectively captures both global topologies and subtle “activity cliff” perturbations.
Chaoyang Xie, Junhu Xu, Guangyi Huang, Shihang Wang, Mutian He, Xinyu Dong, Huiyang Hong, Xiaojun Yao, Qi Wang, Yuquan Li   +9 more
wiley   +1 more source

VIRTUAL LEARNING ENVIRONMENT IN PEDIATRIC RHEUMATOLOGY FOR PEDIATRIC RESIDENTS. [PDF]

Rev Paul Pediatr, 2020
Cunha ALG, Terreri MT, Len CA.
europepmc   +1 more source

Multi‐View Biomedical Foundation Models for Molecule‐Target and Property Prediction

Advanced Science, EarlyView.
Molecular foundation models can provide accurate predictions for a large set of downstream tasks. We develop MMELON, an approach that integrates pre‐trained graph, image, and text foundation models and validate our multi‐view model on over 120 tasks, including GPCR binding.
Parthasarathy Suryanarayanan, Yunguang Qiu, Shreyans Sethi, Diwakar Mahajan, Hongyang Li, Yuxin Yang, Elif Eyigoz, Aldo Guzmán‐Sáenz, Daniel E. Platt, Timothy H. Rumbell, Kenney Ng, Sanjoy Dey, Myson Burch, Bum Chul Kwon, Pablo Meyer, Feixiong Cheng, Jianying Hu, Joseph A. Morrone   +17 more
wiley   +1 more source

His‐MMDM: Multi‐Domain and Multi‐Omics Translation of Histopathological Images with Diffusion Models

Advanced Science, EarlyView.
His‐MMDM is a diffusion model‐based framework for scalable multi‐domain and multi‐omics translation of histopathological images, enabling tasks from virtual staining, cross‐tumor knowledge transfer, and omics‐guided image editing. ABSTRACT Generative AI (GenAI) has advanced computational pathology through various image translation models.
Zhongxiao Li, Tianqi Su, Bin Zhang, Wenkai Han, Sibin Zhang, Guiyin Sun, Yuwei Cong, Xin Chen, Jiping Qi, Yujie Wang, Shiguang Zhao, Hongxue Meng, Peng Liang, Xin Gao   +13 more
wiley   +1 more source

Interculturality, public health and health education: data report based on the Virtual Learning Environment of the Brazilian Health System (AVASUS). [PDF]

Front Public Health
da Cunha PS, Batista NADN, Fernandes F, Barbalho I, Romão MH, Coutinho KMD, Valentim J, Lacerda JS, Dias AP, Henriques S, Valentim R, Alves F, Coutinho KD.   +12 more
europepmc   +1 more source

Fostering teaching-learning through workplace based assessment in postgraduate chemical pathology residency program using virtual learning environment. [PDF]

BMC Med Educ, 2020
Jafri L, Siddiqui I, Khan AH, Tariq M, Effendi MUN, Naseem A, Ahmed S, Ghani F, Alidina S, Shah N, Majid H.   +10 more
europepmc   +1 more source

Modification Strategies of Carbon‐Based Electrodes From Structural Regulation to Multifunctional Integration

Advanced Science, EarlyView.
Tracing the evolution from structural regulation to multifunctional integration, this paper systematically analyzes modification strategies for carbon‐based electrodes. It evaluates how element doping, surface functionalization, and composite material design affect the electrode performance, and offers perspectives on future applications and challenges
Yunlei Wang, Shitao Dou, Yifan Wu, Mingguang Wang, Taibin Wu   +4 more
wiley   +1 more source

Jordanian English language educators' perceived readiness for virtual learning environment. [PDF]

Heliyon
Madanat H, Ab Rashid R, Hashmi UM, Alqaryouti MH, Mohamed M, Al Smadi OA.   +5 more
europepmc   +1 more source

Active Thermal Metasurfaces Enable Superscattering of Thermal Signatures Across Arbitrary Shapes and Thermal Conductivities

Advanced Science, EarlyView.
This study proposes a thermal superscatterer capable of manipulating thermal scattering signatures far exceeding the actual scale of objects. Utilizing transformation thermotics and active thermal metasurfaces, the device reproduces the thermal scattering signature of the enlarged thermal scatterer.
Yichao Liu, Yawen Qi, Fei Sun, Jinyuan Shan, Hanchuan Chen, Yuying Hao, Hongming Fei, Binzhao Cao, Xin Liu, Zhuanzhuan Huo   +9 more
wiley   +1 more source