Results 171 to 180 of about 7,214 (256)

A cryptic allosteric pocket shapes isoform‐selective inhibition of human malic enzymes

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Malic enzymes (ME) regulate central carbon metabolism and cellular redox balance, and the mitochondrial isoform ME2 is frequently upregulated in aggressive cancers to support metabolic flexibility and stress resistance. Isoform‐selective inhibition has remained out of reach because the catalytic machinery is essentially invariant across the ...
Ben A. Krinkel, Yuliana Yosaatmadja, Mark D. Slayton, Anita Krinkel, Jack Copping, Jin Heon Jeon, Joyce Eu, Kerslee Kohagen, Amir Ashoorzadeh, Jeff Smaill, Jack Flanagan, Christopher Walker, Sofia D. Merajver, Kerry Loomes, Christopher J. Squire   +14 more
wiley   +1 more source

Artificial Intelligence Virtual Organoids (AIVOs). [PDF]

Bioact Mater
Bai L, Su J.
europepmc   +1 more source

Crisis Leadership Beyond the Flame: A Human‐Centered Crisis Expectations Model and Its Implications for Research, Policy, and Practice

Risk, Hazards &Crisis in Public Policy, Volume 17, Issue 3, September 2026.
ABSTRACT Disasters and crises disrupt lives and test the capacities of governments and organizations. While their immediate aftermath is often marked by uncertainty and disruption, recurrent patterns in how individuals are affected give rise to foreseeable hardships.
Michel L. A. Dückers
wiley   +1 more source

An intelligent job scheduling and real-time resource optimization for edge-cloud continuum in next generation networks. [PDF]

Sci Rep
Naeem AB, Senapati B, Rasheed J, Baili J, Osman O.   +4 more
europepmc   +1 more source

Large Language Models in Electrical and Computer Engineering Education: Opportunities, Challenges and the Road Ahead

European Journal of Education, Volume 61, Issue 3, September 2026.
ABSTRACT Electrical and Computer Engineering (EE/CE) education encompasses the rigorous study of electronic systems, computing architectures, embedded platforms, signal processing and hardware–software integration. Its inherently multidisciplinary nature demands mastery of mathematical modelling and experimental validation skills that pose substantial ...
Abdulmalik Alwarafy
wiley   +1 more source

Machine learning-enhanced nano-QSAR and multiscale modeling for predictive nanomedicine: applications in herbal therapeutics and neglected tropical diseases. [PDF]

Discov Nano
Abor EK, Addy HPK, Sarpong EA, Sam PK, Anning AS, Ghartey-Kwansah G, Armah FA.   +6 more
europepmc   +1 more source

Demographic Dynamics and International Trade: Stylized Facts and Theoretical Insights

Journal of Economic Surveys, Volume 40, Issue 4, Page 1806-1833, September 2026.
ABSTRACT Demographic change within a country has economic repercussions for other countries through international transactions. Ongoing shifts in population size and age structure across countries have important implications for international trade, operating through changes in market size, consumption preferences, and labor supply.
Kumuthini Sivathas
wiley   +1 more source

Identification and validation of γ-Linolenic acid as a natural FABP5 inhibitor in hepatocellular carcinoma through deep learning and experimental approaches. [PDF]

Front Immunol
An Y, Liu H, Li W.
europepmc   +1 more source

War as a Phenomenon of Inquiry in Management Studies

Journal of Management Studies, Volume 63, Issue 6, Page 2363-2397, September 2026.
Abstract We argue that war as a phenomenon deserves more focused attention in management. First, we highlight why war is an important and relevant area of inquiry for management scholars. We then integrate scattered conversations on war in management studies into a framework structured around three building blocks – (a) the nature of war from an ...
Fabrice Lumineau, Arne Keller
wiley   +1 more source

Artificial intelligence in drug research and development: a review of methods and applications in drug repurposing. [PDF]

Brief Bioinform
Zielińska A, Fornalik M, Szczepaniak M, Gimla M, Lemańska A, Cielecka-Piontek J, Souto EB.   +6 more
europepmc   +1 more source