Results 191 to 200 of about 98,682 (301)

Evaluation of interactive digital art healing effects based on multi modal physiological signals and generative adversarial networks (GANs): an empirical study of the neural mechanisms of emotion regulation. [PDF]

Front Psychol
Xu Z, Xia B.
europepmc   +1 more source

Revisiting Target‐Aware de novo Molecular Generation with TarPass: Between Rational Design and Texas Sharpshooter

Advanced Science, EarlyView.
TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin, Zijie Chen, Yurong Li, Meijing Fang, Longji Shen, Yilong Su, Odin Zhang, Qinghan Wang, Qun Su, Jike Wang, Tingjun Hou, Yu Kang   +11 more
wiley   +1 more source

In Silico Identification of Dual-Action Compounds Targeting TLR2 and <i>Streptococcus mutans</i> Proteins for the Prevention of Early Childhood Caries. [PDF]

Dent J (Basel)
Guzmán-Flores JM, Meza-Rodríguez S, Vázquez-Jiménez SI, Medrano-González IDC, Gallegos-García BL, Hernández-Villalobos AL, Yañez-Acosta MF, Alonso-Sanchez CC.   +7 more
europepmc   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

Design of a mixed reality-based digital twin human-machine interaction system for special working conditions. [PDF]

Front Robot AI
Li S, Hu Y, Li H, Xu J, Li M, Zhang Y, Ren Q.   +6 more
europepmc   +1 more source

Dependability Benchmarking of Network function Virtualization. [PDF]

, 2017
Network Function Virtualization (NFV) is an emerging networking paradigm that aims to reduce costs and time-to-market, improve manageability, and foster competition and innovative services. NFV exploits virtualization and cloud computing technologies to turn physical network functions into Virtualized Network Functions (VNFs), which will be implemented
openaire   +1 more source

A Soft Mechanoluminescent Skin for High‐Resolution Optical Tactile Sensing in Human–Machine Interaction

Advanced Science, EarlyView.
A soft mechanoluminescent tactile sensor that converts force directly into light is presented, enabling imaging‐based, wiring‐free touch sensing. By integrating a flexible ML‐skin with CMOS readout, the system achieves high sensitivity, fast response, and high spatial resolution, while maintaining structural simplicity and energy efficiency, offering a
Yu Feng, Qiaojiao Wang, Yehui Liu, Jiankun Li, Senlin Hou, Xiaomeng Yang, Ziyi Li, Yanji Yi, Meng Chen, Guanglie Zhang, Hao Sun, Wen Jung Li   +11 more
wiley   +1 more source

Human mobility in the metaverse mirrors patterns in the physical world. [PDF]

Sci Rep
Vasan K, Karsai M, Barabási AL.
europepmc   +1 more source

Shear‐Induced Emergence of Aromatic Superlow‐Friction Interfaces in Amorphous Carbon: Triggering Chemical Impurities and Atomic‐Scale Mechanisms

Advanced Science, EarlyView.
High‐throughput quantum‐mechanical simulations reveal that amorphous carbon undergoes shear‐driven structural transformation into aromatic, graphene‐like interfaces. This mechanochemical process is governed by dopant chemistry: dopants with valency less than four promote the emergence of superlow‐friction amorphous graphene, whereas tetra‐valent ...
Takuya Kuwahara, Koki Horiguchi, Leonhard Mayrhofer, Gianpietro Moras, Michael Moseler   +4 more
wiley   +1 more source

From Algorithms to Assets: A Comprehensive Review of AI's Role in Preclinical Drug Discovery and the Hurdles to Clinical Translation. [PDF]

Pharmaceuticals (Basel)
Cai M, Liu T.
europepmc   +1 more source