Results 171 to 180 of about 186,627 (254)

A Guide for Spatial Omics Technologies: Innovation, Evaluation, and Application

open access: yesAdvanced Science, EarlyView.
This review presents a strategy‐centric framework for spatial omics technologies, organizing methods by how spatial information is experimentally encoded. It compares key performance trade‐offs across sequencing‐ and imaging‐based approaches, examines computational and practical limitations, and highlights biomedical applications. The analysis provides
Xiaofeng Wu   +5 more
wiley   +1 more source

Non-linear model predictive control for variable speed hydropower. [PDF]

open access: yesSci Rep
Nepal T   +5 more
europepmc   +1 more source

Why Computational Photochemistry Is Challenging and Will Probably Remain So: A Quantum Chemist's Perspective

open access: yesAdvanced Science, EarlyView.
Computational Photochemistry has made great strides in recent decades, but the investigation of larger molecules remains a challenge due to the inherent dilemma between the increasing computational accuracy required as the molecule size increases and the inevitable explosion in computational effort.
Andreas Dreuw
wiley   +1 more source

FASLG Derived from Fibroblasts in Hydroxyapatite‐Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure

open access: yesAdvanced Science, EarlyView.
Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu   +14 more
wiley   +1 more source

Influence of Hydrogen‐Incorporation on the Bulk Electronic Structure and Chemical Bonding in Palladium

open access: yesAdvanced Science, EarlyView.
Hydrogen incorporation in palladium is directly probed using in situ ambient‐pressure hard X‐ray photoelectron spectroscopy under realistic, application‐relevant conditions. Correlated structural, spectroscopic, and theoretical analysis reveals how hydrogen loading modifies structure, electronic structure, and metal‐hydrogen bonding, resolving long ...
Lars J. Bannenberg   +8 more
wiley   +1 more source

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

open access: yesAdvanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra   +6 more
wiley   +1 more source

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